Soluble CD36 in Plasma Is Increased in Patients With Symptomatic Atherosclerotic Carotid Plaques and Is Related to Plaque Instability
Soluble CD36 in Plasma Is Increased in Patients With Symptomatic Atherosclerotic Carotid Plaques and Is Related to Plaque Instability
复制标题
DOI：
10.1161/strokeaha.108.517128
复制
发表时间：
2008-11-01
期刊：
影响因子：
8.3
通讯作者：
Halvorsen, Bente
中科院分区：
文献类型：
--
作者：
Handberg, Aase;Skjelland, Mona;Halvorsen, Bente
背景和目的心血管事件的风险与炎症和脂质沉积引起的动脉粥样硬化斑块的组成和稳定性有关。清道夫受体是参与脂质摄取和炎症的细胞表面受体家族。最近，我们发现，可溶性CD 36增加血浆中的糖尿病患者强烈相关insulinresistance. Methods，我们测试是否可溶性CD 36是斑块稳定性的标志物，在高级别的颈内动脉狭窄患者（n = 62）。根据超声检查斑块回声和斑块形态对患者进行分类（即，过去2个月内有症状[n = 16]，过去2 - 6个月内有症状[n = 15]，或无症状[n = 31]），与其他两组相比，前者血浆可溶性CD 36水平显著升高。相比之下，我们发现这些组之间的血浆C反应蛋白、β-血小板球蛋白、脂质参数或HbA 1C水平无差异。颈动脉回声斑块组（n = 20）血浆可溶性CD 36水平高于回声斑块组（n = 39; P = 0.087）。通过免疫组化，CD 36被定位到巨噬细胞丰富的区域内膜内的动脉粥样硬化lesion. Conclusion，我们建议，sCD 36可能是斑块不稳定性和症状性颈动脉粥样硬化的标志物，可能至少部分作为结果的CD 36释放到循环中的泡沫细胞内的动脉粥样硬化病变。（中风。2008; 39：3092-3095）。
Background and Purpose-The risk for cardiovascular events is related to the composition and stability of an atherosclerotic plaque driven by inflammation and deposition of lipids. Scavenger receptors are a family of cell surface receptors involved in lipid uptake and inflammation. Recently, we found that soluble CD36 is increased in plasma from patients with diabetes strongly correlated with insulin resistance.Methods-We tested whether soluble CD36 is a marker of plaque stability in patients with high-grade internal carotid stenoses (n = 62). The patients were classified according to plaque symptomatology and plaque echogenicity on ultrasound examination.Results-When patients were divided into 3 groups according to the latest clinical symptoms from plaques (ie, symptoms within the last 2 months [n = 16], symptoms within the last 2 to 6 months [n = 15], or asymptomatic [n = 31]), the former group had significantly raised plasma levels of soluble CD36 as compared with the other 2 groups. In contrast, we found no differences in plasma levels of C-reactive protein, beta-thromboglobulin, lipid parameters, or HbA1C between these groups. The patients with echolucent carotid plaques (n = 20) tended to have higher soluble CD36 levels in plasma compared with those with echogenic/heterogenic plaque(n = 39; P = 0.087). By immunohistochemistry, CD36 was localized to macrophages-rich area of intima within the atherosclerotic lesion.Conclusion-We propose that sCD36 may be a marker of plaque instability and symptomatic carotid atherosclerosis, possibly at least partly as a result of CD36 release to the circulation from the foam cells within the atherosclerotic lesion. (Stroke. 2008; 39: 3092-3095.)