Near-Infrared Light-Controllable Multifunction Mesoporous Polydopamine Nanocomposites for Promoting Infected Wound Healing
Near-Infrared Light-Controllable Multifunction Mesoporous Polydopamine Nanocomposites for Promoting Infected Wound Healing
复制标题
近红外光可控多功能介孔聚多巴胺纳米复合材料促进感染伤口愈合
DOI：
10.1021/acsami.1c19209
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发表时间：
2022-01-05
影响因子：
9.5
通讯作者：
Zhang, Yun
中科院分区：
文献类型：
--
作者：
Zeng, Wei-Nan;Wang, Duan;Zhang, Yun
感染伤口的成功治疗需要具有有效抗菌、抗炎和促进愈合特性的策略。因此，使用Cu 2+和四环素（TC），其可以促进伤口部位的血管生成、再上皮化和胶原沉积，以及抗菌活性，在促进感染伤口修复中显示出应用前景。然而，实现可控释放以延长作用时间并避免潜在毒性是关键。此外，据报道，近红外光（NIR）激活的介孔聚多巴胺纳米颗粒（MPDA NPs）通过消除炎症反应期间产生的活性氧来发挥抗炎作用。在这项研究中，我们评估了负载在MPDA NPs中的Cu 2+和TC是否可以加速小鼠感染伤口的愈合。特别地，将Cu 2+螯合并固定在MPDA NP的表面上，而将热敏相变材料（PCM;熔点：39-40 ° C）与抗生素组合作为看门人（PPMD@Cu/TC）加载到MPDA NP中。结果表明，PPMD@Cu/TC在近红外辐照下表现出明显的光热性能，在近红外辐照下，PPMD@Cu/TC表现出明显的光热性能，在释放Cu ~（2+）的同时，也导致PCM熔融，进而释放TC。结合抗炎治疗，NIR触发的Cu 2+和TC释放使纳米复合材料能够根除细菌伤口感染并加速愈合。重要的是，在小鼠模型中观察到对主要器官的损伤可忽略不计，生物相容性令人满意。总的来说，这些发现突出了这种基于MPDA的平台在控制细菌感染和加速伤口愈合方面的治疗潜力。
The successful treatment of infected wounds requires strategies with effective antimicrobial, anti-inflammatory, and healing-promoting properties. Accordingly, the use of Cu2+ and tetracycline (TC), which can promote angiogenesis, reepithelialization, and collagen deposition, also antibacterial activity, at the wound site, has shown application prospects in promoting infected wound repair. However, realizing controllable release to prolong action time and avoid potential toxicities is critical. Moreover, near-infrared light (NIR)-activated mesoporous polydopamine nanoparticles (MPDA NPs) reportedly exert antiinflammatory effects by eliminating the reactive oxygen species generated during inflammatory responses. In this study, we assess whether Cu2+ and TC loaded in MPDA NPs can accelerate infected wound healing in mice. In particular, Cu2+ is chelated and immobilized on the surface of MPDA NPs, while a thermosensitive phase-change material (PCM; melting point: 39-40 degrees C), combined with antibiotics, was loaded into the MPDA NPs as a gatekeeper (PPMD@Cu/TC). Results show that PPMD@Cu/TC exhibits significant great photothermal properties with NIR irradiation, which induces the release of Cu2+, while inducing PCM melting and, subsequent, TC release. In combination with anti-inflammatory therapy, NIR-triggered Cu2+ and TC release enables the nanocomposite to eradicate bacterial wound infections and accelerate healing. Importantly, negligible damage to primary organs and satisfactory biocompatibility were observed in the murine model. Collectively, these findings highlight the therapeutic potential of this MPDA-based platform for controlling bacterial infection and accelerating wound healing.