Comparison of the incidence of oncogenic transformation produced by X rays, misonidazole, and chemotherapy agents.
Comparison of the incidence of oncogenic transformation produced by X rays, misonidazole, and chemotherapy agents.
复制标题
X射线、米索硝唑和化疗药物产生的致癌转化发生率的比较。
DOI：
10.1148/radiology.145.2.6182579
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发表时间：
1982
期刊：
影响因子：
19.7
通讯作者：
Zimmerman,M
中科院分区：
文献类型：
--
作者：
Hall,EJ;Miller,RC;Osmak,R;Zimmerman,M
建立了体外培养的小鼠成纤维细胞系(10T1/2细胞)，比较了X射线、低氧细胞放射增敏剂米索硝唑和一系列常用化疗药物对肿瘤转化的影响。在治疗过程中以可获得的浓度暴露于米索硝唑3天，可产生类似于约50rad的转化发生率。当化疗剂的浓度与临床上使用的浓度相当，并与产生类似细胞杀伤力的药物相匹配时，转化的发生率差异很大：一些试剂，如长春新碱，不会产生高于本底水平的转化，而另一些试剂，如顺铂，似乎是强烈的致癌物，产生转化的速度比X射线高出数量级。
An established line of mouse fibroblasts (10T1/2 cells) cultured in vitro was used to compare the incidence of oncogenic transformation produced by x rays, the hypoxic cell radiosensitizer misonidazole, and a range of commonly used chemotherapy agents. A 3-day exposure to misonidazole at a concentration obtainable during treatment produced an incidence of transformation similar to that of about 50 rad. When chemotherapy agents were tested at concentrations comparable to those used clinically and matched to produce similar cell killing, the incidence of transformation varied widely: some agents, such as vincristine, did not produce transformation at a level detectable above background, while others, such as cis-platinum, appear to be potent carcinogens and produce transformation at a rate orders of magnitude higher than that achieved with x rays.