The influence of somatic maturity on the relationship between the triglyceride/high-density lipoprotein ratio and vascular health in children and adolescents with dyslipidemia.
The influence of somatic maturity on the relationship between the triglyceride/high-density lipoprotein ratio and vascular health in children and adolescents with dyslipidemia.
复制标题
体细胞成熟度对血脂异常儿童和青少年甘油三酯/高密度脂蛋白比值与血管健康关系的影响。
DOI：
10.1002/ajhb.23815
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
White,DavidA
中科院分区：
文献类型：
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作者：
Talluri,Rachna;Sherman,AshleyK;Goth,Natalie;Simpson,Kayla;Kuzava,Laura;Raghuveer,Geetha;White,DavidA
IntroductionTwo的甘油三酯高密度脂蛋白胆固醇（TG/HDL）的比例和青春期成熟的时间已被确定为独立的贡献者的发展动脉粥样硬化。我们的研究的目的是确定TG/HDL的比例和措施之间的关系血管健康的儿童和青少年血脂异常分层的躯体成熟。我们假设，躯体成熟将有一个显着的相互作用与TG/HDL比率和血管health.MethodsThis是一个纵向分析120名儿童和青少年（年龄8-14岁）与血脂异常招募从儿科预防心脏病诊所。在基线和每次随访时，收集非空腹血清脂质组，并评估血管健康（颈动脉内膜-中膜厚度，脉搏波速度，增强指数）。在每次访视时计算峰值身高增长速度（PHV），并将参与者按成熟度偏移（PHV前、PHV中、PHV后）分层。混合模型设计允许基线和后续访问被归类为离散datapoints.ResultsOf的n=235个数据点（前PHV = 23%，中期PHV = 19%，和后PHV =58%），我们确定TG/HDL比率，成熟偏移和血管结构或功能的措施之间没有显着的相互作用。TG/HDL与成熟组无明显相关性。在青春期中期组，TG/HDL和增强index.ConclusionDespite之间的关系很弱，青春期早期成熟和成年期心血管危险因素的发展之间的关系，我们发现，血管损伤导致TG/HDL比率升高是不独立与躯体成熟。
IntroductionBoth the triglyceride to HDL cholesterol (TG/HDL) ratio and timing of pubertal maturation have been identified as independent contributors to the development of atherosclerosis.ObjectiveThe purpose of our study was to determine the relationship between the TG/HDL ratio and measures of vascular health in children and adolescents with dyslipidemia stratified by somatic maturity. We hypothesized that somatic maturity would have a significant interaction with TG/HDL ratio and vascular health.MethodsThis was a longitudinal analysis of 120 children and adolescents (age 8-14 years) with dyslipidemia recruited from a pediatric preventive cardiology clinic. At baseline and each follow-up visit, a non-fasting serum lipid panel was collected and vascular health (carotid artery intima--media thickness, pulse wave velocity, augmentation index) was assessed. Peak height velocity (PHV) was calculated at each visit, and participants were stratified into groups by maturity offset (pre-PHV, mid-PHV, post-PHV). A mixed model design permitted baseline and follow-up visits to be classified as discrete data points.ResultsOf the n=235 data points (pre-PHV=23%, mid-PHV=19%, and post-PHV=58%), we identified no significant interaction between TG/HDL ratio, maturity offset, and measures of vascular structure or function. There was also no significant relationship found between TG/HDL and maturity group. Within the mid-pubertal group, there was weak relationship found between TG/HDL and augmentation index.ConclusionDespite the well-described relationship between early pubertal maturation and development of cardiovascular risk factors in adulthood, we found that vascular damage resulting from an elevated TG/HDL ratio is not independently associated with somatic maturity.