Successful Control of Disseminated Intravascular Coagulation by Recombinant Thrombomodulin during Arsenic Trioxide Treatment in Relapsed Patient with Acute Promyelocytic Leukemia.
Successful Control of Disseminated Intravascular Coagulation by Recombinant Thrombomodulin during Arsenic Trioxide Treatment in Relapsed Patient with Acute Promyelocytic Leukemia.
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DOI：
10.1155/2012/908196
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发表时间：
2012
影响因子：
0.7
通讯作者：
Kohgo Y
中科院分区：
文献类型：
--
作者：
Shindo M;Ikuta K;Addo L;Ito S;Fujiya M;Torimoto Y;Kohgo Y
急性早幼粒细胞白血病（APL）患者常发生弥散性血管内凝血（DIC）。随着全反式维甲酸（ATRA）在APL中的诱导治疗，DIC在大多数情况下可以得到控制，因为ATRA通常显示APL的立即改善。然而，三氧化二砷（ATO）已被用于治疗APL患者的复发，已显示需要时间来抑制APL细胞，因此ATO治疗APL的DIC控制是一个主要问题。近年来，重组可溶性血栓调节蛋白片段作为治疗DIC的高效新药受到了广泛关注。在这里，我们提出了一个复发的APL患者，其中DIC成功和安全地控制与ATO治疗期间的rTM。
Disseminated intravascular coagulation (DIC) frequently occurs in patients with acute promyelocytic leukemia (APL). With the induction of therapy in APL using all-trans retinoic acid (ATRA), DIC can be controlled in most cases as ATRA usually shows immediate improvement of the APL. However, arsenic trioxide (ATO) which has been used for the treatment of relapse in APL patients has shown to take time to suppress APL cells, therefore the control of DIC in APL with ATO treatment is a major problem. Recently, the recombinant soluble thrombomodulin fragment has received a lot of attention as the novel drug for the treatment of DIC with high efficacy. Here, we present a relapsed patient with APL in whom DIC was successfully and safely controlled by rTM during treatment with ATO.