Antibacterial property expressed by a novel calcium phosphate glass.
Antibacterial property expressed by a novel calcium phosphate glass.
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新型磷酸钙玻璃表现出抗菌性能。
DOI：
10.1002/jbm.b.33019
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Zhang,Yu
中科院分区：
文献类型：
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作者：
Liu,Lela;Pushalkar,Smruti;Saxena,Deepak;LeGeros,RacquelZ;Zhang,Yu
我们开发了一种掺杂Zn 2+或F−或Zn 2+和F−离子的磷酸钙玻璃（CPG），这些离子天然存在于人体中，在骨形成和抗菌活性中发挥双重作用。以前，我们已经证明了这个CPG家族在体内具有上级骨传导性和可吸收性。本研究的目的是研究含Zn 2+和/或F−的CPG的抗菌性能。我们使用变形链球菌作为模式生物，因为它是人类口腔主要病原体之一，也是早期定植者，并且与几种口腔感染有关，如龋齿、牙周炎和种植体炎。0.01和0.05 g CPG与S.诱变0、2、4和6 h。将系列稀释液一式三份铺板，并测定菌落形成单位。结合Zn 2+或F−的CPG的抗微生物效果大于结合这两种离子的CPG。没有掺杂的CPG产生中等的抗菌效果。这个CPG家族，以前被证明在体内促进新骨形成，被证明具有上级杀菌特性。© 2013威利期刊公司. J Biomed Mater Res Part B：Appl Biomater，102 B：423-429，2014.
We have developed a calcium phosphate glass (CPG) doped with Zn2+or F−or combined Zn2+and F−ions, which are naturally found in the human body and play a dual role in bone formation and antibacterial activity. Previously, we have demonstrated that this family of CPGs has superior osteoconductive and resorbable propertiesin vivo. This study aimed to investigate the antibacterial property of CPGs incorporating Zn2+and/or F−. We usedStreptococcus mutansas a model organism because it is one of the major human oral pathogens and an early colonizer, and it has been associated with several oral infections, such as dental caries, periodontitis, and peri‐implantitis. CPGs of 0.01 and 0.05 g were incubated withS. mutansfor 0, 2, 4, and 6 h. Serial dilutions were plated in triplicate and colony forming units were determined. The antimicrobial effect of CPG incorporating Zn2+or F−was greater than CPG incorporating both these ions. CPG without doping produced a moderate antimicrobial effect. This family of CPGs, previously shown to promote new bone formationin vivo,is demonstrated to have superior bactericidal properties. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 423–429, 2014.