Clearance: The cast and often forgotten stage of apoptosis
Clearance: The cast and often forgotten stage of apoptosis
复制标题
清除： 凋亡过程中经常被遗忘的阶段
DOI：
10.1023/a:1011384009787
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发表时间：
1999-04-01
影响因子：
2.5
通讯作者：
Fadok, VA
中科院分区：
文献类型：
--
作者：
Fadok, VA
被吞噬细胞吞噬是大多数凋亡细胞生命中最后的常见事件。凋亡小体在裂解之前的吞噬作用可防止潜在有毒或免疫原性细胞内内容物的释放，并激活抗炎反应，至少在巨噬细胞中如此。我们开始了解巨噬细胞和其他吞噬细胞在体外识别凋亡细胞的机制，但距离确定它们在体内的相对重要性还有很长的路要走。退化的乳腺因细胞凋亡而经历大量细胞损失。垂死的肺泡上皮细胞可以脱落到管腔中，或者可以被巨噬细胞和活的上皮细胞吞噬。然而，我们对乳腺识别和摄取的介导机制几乎一无所知。凋亡细胞的清除可能对于腺体的正常重塑为下一波哺乳做好准备至关重要。因此，乳腺提供了一个理想的器官来研究体内凋亡细胞清除的机制和后果。
Engulfment by a phagocyte is the final common event in the life of most apoptotic cells. Phagocytosis of apoptotic bodies prior to their lysis prevents the release of potentially toxic or immunogenic intracellular contents and activates an anti-inflammatory response, at least in macrophages. We are beginning to understand the mechanisms by which macrophages and other phagocytes recognize apoptotic cells in vitro, but we are a long way from determining their relative importance in vivo. The involuting mammary gland undergoes massive cell loss by apoptosis. The dying alveolar epithelial cells can be shed into the lumen or can be phagocytosed by macrophages and viable epithelial cells. Yet we know virtually nothing about the mechanisms mediating recognition and uptake in the mammary gland. It is likely that clearance of apoptotic cells is critical to normal remodeling of the gland in preparation for the next wave of lactation. The mammary gland, therefore, provides an ideal organ in which to study the mechanisms and consequences of apoptotic cell clearance in vivo.