Lineage does not regulate the sensory synaptic input of projection neurons in the mouse olfactory bulb
Lineage does not regulate the sensory synaptic input of projection neurons in the mouse olfactory bulb
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DOI：
10.7554/elife.46675
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发表时间：
2019-08
期刊：
影响因子：
7.7
通讯作者：
Luis Sánchez-Guardado;C. Lois
中科院分区：
文献类型：
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作者：
Luis Sánchez-Guardado;C. Lois
谱系调节无脊椎动物神经系统某些区域的神经元之间的突触连接。在哺乳动物中，最近的实验表明，细胞谱系决定了新皮质中锥体神经元的连接性，但这种现象的功能相关性以及它是否发生在其他神经元类型中仍然存在争议。我们研究了谱系是否在二尖瓣细胞和簇状细胞（小鼠嗅球中的投射神经元）的连接中发挥作用。我们使用转基因小鼠稀疏地标记神经元祖细胞，并观察到克隆相关神经元接收来自表达不同嗅觉受体的嗅觉感觉神经元的突触输入。这些结果表明谱系并不决定嗅觉感觉神经元和嗅球投射神经元之间的连接。
Lineage regulates the synaptic connections between neurons in some regions of the invertebrate nervous system. In mammals, recent experiments suggest that cell lineage determines the connectivity of pyramidal neurons in the neocortex, but the functional relevance of this phenomenon and whether it occurs in other neuronal types remains controversial. We investigated whether lineage plays a role in the connectivity of mitral and tufted cells, the projection neurons in the mouse olfactory bulb. We used transgenic mice to sparsely label neuronal progenitors and observed that clonally related neurons receive synaptic input from olfactory sensory neurons expressing different olfactory receptors. These results indicate that lineage does not determine the connectivity between olfactory sensory neurons and olfactory bulb projection neurons.