DETECTION OF EARLY LUNG-CANCER USING LOW-DOSE PHOTOFRIN-II
DETECTION OF EARLY LUNG-CANCER USING LOW-DOSE PHOTOFRIN-II
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DOI：
10.1378/chest.97.2.333
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发表时间：
1990-02-01
期刊：
影响因子：
9.6
通讯作者：
PROFIO, AE
中科院分区：
文献类型：
--
作者：
LAM, S;PALCIC, B;PROFIO, AE
以血卟啉衍生物（HpD）或Photofrin Ⅱ作为肿瘤标记物的荧光显像已被用于早期支气管肺癌的定位。HpD或Photofrin II作为癌症显像剂的广泛临床应用受到潜在严重和长期皮肤光敏性的阻碍。使用带有比率荧光计探针的灵敏荧光支气管镜系统，在四名使用低剂量Photofrin II（0.25 mg/kg）的患者中检测到原位癌，皮肤光敏性测试中对30 J/cm 2可见光没有明显的皮肤光毒性。
Fluorescence imaging using hematoporphyrin derivative (HpD) or Photofrin II as a tumor marker has been used for localization of early bronchogenic carrcinoma. Wider clinical application of HpD or Photofrin II as a cancer imaging agent has been hampered by the potentially serious and prolonged skin photosensitivity. Using a sensitive fluorescence bronchoscope system with a ratio fluorometer probe, carcinoma in situ was detected in four patients with low dose Photofrin II (0.25 mg/kg) with no apparent skin phototoxicity to 30 J/cm2 visible light on skin photosensitivity test.