Neurobiological basis for pain vulnerability: why me?
Neurobiological basis for pain vulnerability: why me?
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DOI：
10.1097/j.pain.0000000000000858
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发表时间：
2017-04-01
期刊：
影响因子：
7.4
通讯作者：
McMahon, Stephen B.
中科院分区：
文献类型：
--
作者：
Denk, Franziska;McMahon, Stephen B.
在疼痛研究中进行的大量机械性工作都涉及回答为什么某种刺激应该被感知为疼痛的问题，或者慢性疼痛状态下的神经系统与健康标准有何不同。在这类研究中，感知的个体差异通常被视为一种滋扰--对任何“真实的信号”的干扰。事实上，有大量的噪音要应对：疼痛体验是非常可变的，无论是在健康还是疾病中。在下文中，我们将把这种可变性作为我们审查的重点。我们将概述其存在的证据，讨论可能支持它的各种生物学机制，最后，讨论这种可变性可能对个性化医疗概念产生的潜在影响。
A great deal of mechanistic work conducted in pain research is concerned with answering the question of why a certain stimulus should be perceived as painful or how the nervous system in a chronic pain state differs from the healthy norm. In these kinds of studies, individual differences in perception are usually seen as a nuisance—a distraction from any “real signal.” And indeed, there is a large amount of noise to contend with: pain experiences are extremely variable, both in health and disease. In the following, we are going to make this variability the focus of our review. We will outline the evidence for its existence, discuss the various biological mechanisms that might underpin it, and finally, deliberate on potential implications such variability might have for the concept of personalised medicine.