Modeling Biological Activities of Nanoparticles
Modeling Biological Activities of Nanoparticles
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DOI：
10.1021/nl303144k
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发表时间：
2012-11-01
期刊：
影响因子：
10.8
通讯作者：
Winkler, David A.
中科院分区：
文献类型：
--
作者：
Epa, V. Chandana;Burden, Frank R.;Winkler, David A.
产品越来越多地采用纳米材料，但我们对其不利影响的了解很少。为了评估风险，监管机构需要对纳米颗粒进行更多的实验测试。计算模型在快速预测新的和改性纳米材料的潜在毒性方面发挥着补充作用。我们生成了几种细胞类型的纳米颗粒诱导的细胞摄取和凋亡的定量预测模型。我们说明了潜在的计算方法，使纳米安全的贡献。
Products are increasingly incorporating nanomaterials, but we have a poor understanding of their adverse effects. To assess risk, regulatory authorities need more experimental testing of nanoparticles. Computational models play a complementary role in allowing rapid prediction of potential toxicities of new and modified nanomaterials. We generated quantitative, predictive models of cellular uptake and apoptosis induced by nanoparticles for several cell types. We illustrate the potential of computational methods to make a contribution to nanosafety.