Overexpression of human papillomavirus (HPV) type 16 oncoproteins promotes angiogenesis via enhancing HIF-1 α and VEGF expression in non-small cell lung cancer cells
Overexpression of human papillomavirus (HPV) type 16 oncoproteins promotes angiogenesis via enhancing HIF-1 α and VEGF expression in non-small cell lung cancer cells
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DOI：
10.1016/j.canlet.2011.07.012
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发表时间：
2011-12-08
期刊：
影响因子：
9.7
通讯作者：
Tang, Xudong
中科院分区：
文献类型：
--
作者：
Li, Gang;He, Li;Tang, Xudong
HPV-16感染可能在不吸烟者的非小细胞肺癌（NSCLC）的发展中起重要作用。由于血管生成在非小细胞肺癌发展中的关键作用，我们在这里描述了HPV-16癌蛋白对非小细胞肺癌血管生成的影响及其潜在机制。我们发现在NSCLC细胞中过表达HPV-16 E6和E7癌蛋白可显著促进体外和体内血管生成，相应的，HIF-1 α和VEGF表达增强，这是肿瘤血管生成的重要促血管生成因子。同时，HPV-16癌蛋白的过度表达也导致HIF-1 α依赖性地增加其他几种促血管生成因子的分泌，包括IL-8。我们的研究结果表明，HPV-16癌蛋白可能通过促进HIF-1 α / vegf介导的肿瘤血管生成而促进NSCLC的发展。2011爱思唯尔爱尔兰有限公司版权所有。
HPV-16 infection may play an important role in the development of non-small cell lung cancer (NSCLC) among never-smokers. Due to the critical role of angiogenesis in NSCLC development, we describe here the effect of HPV-16 oncoproteins on angiogenesis in NSCLC and the underlying mechanisms. We found that overexpression of HPV-16 E6 and E7 oncoproteins in NSCLC cells significantly promoted angiogenesis both in vitro and in vivo, and correspondingly, an enhanced expression of HIF-1 alpha and VEGF, important pro-angiogenic factors in tumor angiogenesis. Meanwhile, overexpression of HPV-16 oncoproteins also led to HIF-1 alpha-dependent increases in the secretion of several other pro-angiogenic factors, including IL-8. Our findings suggest that HPV-16 oncoproteins contribute to the development of NSCLC possibly by promoting HIF-1 alpha/VEGF-mediated tumor angiogenesis. (C) 2011 Elsevier Ireland Ltd. All rights reserved.