Postnatal ontogeny of cholecystokinin receptors in rat brain
Postnatal ontogeny of cholecystokinin receptors in rat brain
复制标题
大鼠脑中胆囊收缩素受体的出生后个体发育
DOI：
10.1016/0006-8993(81)91269-5
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发表时间：
1981
期刊：
影响因子：
2.9
通讯作者：
S. Paul
中科院分区：
文献类型：
--
作者：
S. E. Hays;S. H. Houston;M. Beinfeld;S. Paul
本研究测定了大鼠脑内胆囊收缩素受体和胆囊收缩素的生后个体发育。胆囊收缩素（CCK）与大鼠前脑受体的结合在1-2日龄时非常低，在12日龄时达到最大值（Bmax= 31 fmol/mg蛋白，Kd= 1.47 nM），并在26日龄时下降至成人水平（Bmax= 17 fmol/mg蛋白，Kd= 1.39 nM）。与此相反，前脑CCK浓度测定放射免疫法上升单调通过第27天。CCK受体的瞬时发育高峰的可能影响进行了讨论。
The postnatal ontogeny of cholecystokinin receptors and cholecystokinin was determined in rat brain. The binding of cholecystokinin (CCK) to rat forebrain receptors was very low at 1–2 days of age, rose to a maximum at 12 days (Bmax= 31 fmol/mg protein,Kd= 1.47 nM), and declined to adult levels by 26 days (Bmax= 17 fmol/mg protein,Kd= 1.39 nM). In contrast, forebrain concentrations of CCK measured by radioimmunoassay rose monotonically through day 27. Possible implications of the transient developmental peak of CCK receptors are discussed.