Synthesis of a major mitomycin C DNA adduct via a triaminomitosene
Synthesis of a major mitomycin C DNA adduct via a triaminomitosene
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DOI：
10.1016/j.bmcl.2012.09.052
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发表时间：
2012-12-01
影响因子：
2.7
通讯作者：
Sapse, Anne-Marie
中科院分区：
文献类型：
--
作者：
Champeil, Elise;Paz, Manuel M.;Sapse, Anne-Marie
We report here the synthesis of two amino precursors for the production of mitomycin C and 10-decarbamoylmitomycin C DNA adducts with opposite stereochemistry at C-1. The triamino mitosene precursors were synthesized in 5 steps from mitomycin C. In addition synthesis of the major mitomycin C-DNA adduct has been accomplished via coupling of a triaminomitosene with 2-fluoro-O-6-(2-p-nitrophenylethyl)deoxyinosine followed by deprotection at the N-2 and O-6 positions. Published by Elsevier Ltd.
