Identification of genes involved in alcohol consumption and cigarettes smoking.
Identification of genes involved in alcohol consumption and cigarettes smoking.
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DOI：
10.1186/1471-2156-6-s1-s112
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发表时间：
2005-12-30
期刊：
影响因子：
2.9
通讯作者：
Slager, SL
中科院分区：
文献类型：
--
作者：
de Andrade, M;Olswold, CL;Slusser, JP;Tordsen, LA;Atkinson, EJ;Rabe, KG;Slager, SL
我们比较了使用单核苷酸多态性和微卫星标记的定量连锁分析的结果，并介绍了一种新的筛选试验的多变量定量连锁分析，使用酒精中毒遗传学的合作研究数据。我们分析了115个扩展的非西班牙裔白色家庭，并使用两种表型进行连锁测试：24小时内的最大饮酒量和一年内每天吸烟的包数。我们的研究结果表明，使用单核苷酸多态性与微卫星标记相比，连锁信号增加，筛选试验给出了类似的结果，双变量分析，这表明其潜在的使用，在减少整体分析时间。
We compared the results of quantitative linkage analysis using single-nucleotide polymorphisms and microsatellite markers and introduced a new screening test for multivariate quantitative linkage analysis using the Collaborative Study on the Genetics of Alcoholism data. We analyzed 115 extended non-Hispanic White families and tested for linkage using two phenotypes: the maximum number of drinks in a 24-hour period and the number of packs smoked per day for one year. Our results showed that the linkage signal increased using single-nucleotide polymorphisms compared with microsatellite markers and that the screening test gave similar results to that of the bivariate analysis, suggesting its potential use in reducing overall analysis time.