Mouse model of DNCB-induced atopic dermatitis
Mouse model of DNCB-induced atopic dermatitis
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DOI：
10.3329/bjp.v12i2.31950
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发表时间：
2017-01-01
影响因子：
1.6
通讯作者：
Rather, Irfan A.
中科院分区：
文献类型：
--
作者：
Hamad, Alshammari Fanar;Han, Jong-Hun;Rather, Irfan A.
特应性皮炎是一种以过敏性皮肤炎症、发红、瘙痒为特征的皮肤病。动物模型对于发现新药是必要的。dncb诱导的特应性皮炎动物模型包括以下几个步骤：1)动物的选择；2)背部皮肤剃须；3)每24小时使用一次DNCB，连续使用三天；4)应用DNCB后第4天监测特异反应的发展情况。此外，参考药物的功效可以通过应用在特应性皮肤上来确定，这取决于工作的性质和目的。
Atopic dermatitis is a skin disease characterized by allergic skin inflammation, redness and itching. The animal model is necessary to find out new drugs. The DNCB-induced animal model of atopic dermatitis includes the following steps: 1) Selection of animals; 2) Shaving of dorsal skin; 3) Applying DNCB once in 24 hours for three days; 4) Monitoring the development of atopy on day 4 post DNCB application. Further, the efficacy of reference drug can be determined by applying on the atopy skin, depends on the nature and aim of the work.