Chronic glaucoma selectively damages large optic nerve fibers.
Chronic glaucoma selectively damages large optic nerve fibers.
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DOI：
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发表时间：
1987-06
影响因子：
4.4
通讯作者：
H. Quigley;Rosario Sanchez;G. Dunkelberger;N. L'Hernault;T. Baginski
中科院分区：
文献类型：
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作者：
H. Quigley;Rosario Sanchez;G. Dunkelberger;N. L'Hernault;T. Baginski
为了确定青光眼是否选择性地损伤特定大小的视神经纤维（及其细胞体），我们在10只猴子的一只眼睛中诱导慢性实验性青光眼。应用自动图像分析仪，比较各患眼与正常眼视神经纤维的数目和直径。大于正常平均直径的纤维萎缩更迅速，在昏迷的眼睛，虽然没有纤维大小免于损害。青光眼眼的平均纤维直径为0.74 μ m，显著低于10只对侧眼的平均值0.85 μ m（P <0.005）。在上级和下级周围神经部分，所有大小的纤维优先出现更大的萎缩，如青光眼患者所见。较大纤维的更快萎缩似乎由两个原因引起。实验性青光眼中纤维损失最快的区域通常含有高比例的较大直径纤维。此外，即使在轻度损伤的视神经区域，较大的纤维也优先丢失，表明它们对青光眼损伤的固有易感性。大纤维在青光眼中丢失的趋势对未来早期青光眼损伤测试的改进具有意义。
To determine whether glaucoma selectively injures a particular size of optic nerve fiber (and its cell body), we induced chronic experimental glaucoma in one eye each of ten monkeys. With automated image analysis, the number and diameter of optic nerve fibers were compared between each glaucomatous eye and its normal fellow eye. Fibers larger than the normal mean diameter atrophied more rapidly in glaucomatous eyes, though no fiber size was spared from damage. The mean fiber diameter for glaucomatous eyes was 0.74 micron, significantly lower than the mean for ten fellow eyes, 0.85 micron (P less than 0.005). There was preferentially greater atrophy of fibers of all sizes in the superior and inferior peripheral nerve sectors, as seen in human eyes with glaucoma. The more rapid atrophy of larger fibers appeared to result from two causes. The areas that suffer most rapid loss of fibers in experimental glaucoma normally contain a high proportion of larger diameter fibers. Furthermore, larger fibers were lost preferentially even in areas of the optic nerve with mild damage, indicating their inherent susceptibility to injury by glaucoma. The tendency for large fibers to be lost in glaucoma has implications for future improvements in testing for early glaucoma damage.