Stg1 is a novel SM22/transgelin-like actin-modulating protein in fission yeast
Stg1 is a novel SM22/transgelin-like actin-modulating protein in fission yeast
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DOI：
10.1016/j.febslet.2005.10.011
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发表时间：
2005-11-21
期刊：
影响因子：
3.5
通讯作者：
Numata, O
中科院分区：
文献类型：
--
作者：
Nakano, K;Bunai, F;Numata, O
我们在裂殖酵母中发现了一种新的肌动蛋白调控蛋白STG1。STG1类似于哺乳动物的SM22/转明胶，生化实验表明STG1是F-肌动蛋白的交联体。显微镜观察表明，STG1是肌动蛋白斑块的一种成分。STG1的过表达通过抑制细胞末端和中部收缩环的形成和F-肌动蛋白异常聚集体的形成而导致胞质分裂的缺陷。尽管破坏STG1(+)对肌动蛋白细胞骨架的分布没有影响，但遗传交互作用表明STG1可能参与控制分裂酵母细胞形态发生和胞质分裂过程中肌动蛋白细胞骨架的组织。(C)2005年欧洲生化学会联合会。爱思唯尔出版，版权所有。
We identified a novel actin-modulating protein Stg1 in the fission yeast Schizosaccharomyces pombe. Stg1 is similar to mammalian SM22/transgelin, and biochemical experiments showed that Stg1 crosslinked F-actin. Microscopic observation suggested that Stg1 was a component of actin patch. Overexpression of Stg1 caused a defect in cytokinesis by suppressing the formation of a contractile ring and formation of abnormal aggregates of F-actin in the ends and mid-region of cells. Although distribution of the actin cytoskeleton was not affected by disrupting stg1(+), genetic interaction suggested that Stg1 was likely involved in controlling the organization of the actin cytoskeleton in cell morphogenesis and cytokinesis in fission yeast. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.