Clinical, Epidemiological, and Histopathological Features of Respiratory Involvement in Rheumatoid Arthritis.
Clinical, Epidemiological, and Histopathological Features of Respiratory Involvement in Rheumatoid Arthritis.
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DOI：
10.1155/2017/7915340
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发表时间：
2017
影响因子：
--
通讯作者：
Carubbi F
中科院分区：
文献类型：
--
作者：
Alunno A;Gerli R;Giacomelli R;Carubbi F
虽然类风湿关节炎（RA）的定义是一种关节紊乱，但它是一种全身性疾病，18-40%的患者有关节外表现（EAMs）。约30-40%的RA患者累及呼吸系统，其中约10-20%为RA的首发表现。RA患者可检测到广泛的肺部表现，包括肺实质疾病、胸膜受累、气道和肺部炎症。RA的临床、放射学和组织学表现反映了慢性免疫激活、对感染的易感性增加（通常与免疫抑制药物有关）或直接药物。肺部受累的类型和严重程度影响预后，从轻微的自限性到严重的危及生命的并发症。在此，我们回顾了RA中呼吸受累的各种表现，提供了流行病学，组织学，临床和放射学资料的概述。
Although by definition rheumatoid arthritis (RA) is an articular disorder, it is a systemic disease, and 18–40% of patients experience extra-articular manifestations (EAMs). The involvement of the respiratory system occurs in about 30–40% of RA patients, and in about 10–20% of them it represents the first manifestation of RA. A wide range of pulmonary manifestations are detectable in RA patients, including pulmonary parenchymal disease, pleural involvement, and airway and pulmonary inflammation. The clinical, radiological, and histological spectra of respiratory manifestations in RA reflect chronic immune activation, increased susceptibility to infection (often related to immunosuppressive medications), or direct drug. The type and severity of pulmonary involvement influence the prognosis, ranging from mild self-limiting conditions to severe life-threatening complications. Herein, we reviewed the various manifestations of respiratory involvement in RA, providing an overview on epidemiological, histological, clinical, and radiological data.
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影响因子：
4.7
作者：
Alunno, Alessia;Caneparo, Valeria;Gerli, Roberto
通讯作者：
Gerli, Roberto
影响因子：
5
作者：
CARSON, CW;CANNON, GW;CLEGG, DO
通讯作者：
CLEGG, DO
影响因子：
2.5
作者：
Greco, Antonio;Fusconi, Massimo;de Vincentiis, Marco
通讯作者：
de Vincentiis, Marco
影响因子：
10
作者：
CAPLAN, A
通讯作者：
CAPLAN, A
影响因子：
3.3
作者：
Carloni, Angelo;Piciucchi, Sara;Poletti, Venerino
通讯作者：
Poletti, Venerino