INHIBITORY EFFECT OF IGM RHEUMATOID-FACTOR ON IMMUNE-COMPLEX SOLUBILIZATION CAPACITY AND INHIBITION OF IMMUNE PRECIPITATION
INHIBITORY EFFECT OF IGM RHEUMATOID-FACTOR ON IMMUNE-COMPLEX SOLUBILIZATION CAPACITY AND INHIBITION OF IMMUNE PRECIPITATION
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DOI：
10.1002/art.1780271008
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发表时间：
1984-01-01
影响因子：
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通讯作者：
BOMBARDIERI, S
中科院分区：
文献类型：
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作者：
BALESTRIERI, G;TINCANI, A;BOMBARDIERI, S
纯化的人IgM类风湿因子(RF，3个单抗和2个多克隆)以剂量依赖的方式抑制补体介导的两种功能，即免疫复合物的溶解能力和免疫沉淀的抑制。仅当RF与补体来源的添加同时而不是在添加补体来源之后添加时，才会抑制免疫复合体的溶解能力。实验证据表明，RF的作用与其抗互补活性无关，而是需要RF与免疫球蛋白分子的Fc区结合。尽管到目前为止还没有可用的临床数据，但这些新描述的RF的特性可能具有生物学意义。
Purified human IgM rheumatoid factors (RF; 3 monoclonal and 2 polyclonal) were shown to inhibit, in a dose-dependent manner, 2 complement-mediated functions, i.e., the immune complex solubilization capacity and the inhibition of immune precipitation. Inhibition of immune complex solubilization capacity occurred only if RF was added at the same time as, but not after, addition of the complement source. Experimental evidence suggests that the effects of RF were not related to their anticomplementary activity, but rather required the attachment of RF to the Fc region of the IgG molecule. Although no clinical data are available so far, it might be plausible that these newly described properties of RF have biologic relevance.