Radiotherapy for Glottic T1N0 Carcinoma with Slight Hypofractionation and Standard Overall Treatment Time: Importance of Overall Treatment Time
Radiotherapy for Glottic T1N0 Carcinoma with Slight Hypofractionation and Standard Overall Treatment Time: Importance of Overall Treatment Time
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DOI：
10.1093/jjco/hyq153
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发表时间：
2011-01-01
影响因子：
2.4
通讯作者：
Shirato, Hiroki
中科院分区：
文献类型：
--
作者：
Onimaru, Rikiya;Hasegawa, Masakazu;Shirato, Hiroki
我们回顾性研究了声门 T1 癌患者每周 4 次、26 次、65 Gy 的治疗结果，并讨论了总治疗时间的重要性。对 201 名声门 T1 癌患者进行了评估。 200 名患者接受了 26 次 65 Gy 照射，而 1 名患者接受了 25 次 62.5 Gy 照射。在此期间，我们每周进行四次放射治疗，每天一次，每周剂量为 10 Gy。除周三外的工作日为治疗日。3 年总生存率为 96.8 +/- 1.3%（标准误差），5 年总生存率为 90.8 +/- 2.2%。 3 年局部控制率为 91.9 +/- 2.0%，5 年局部控制率为 89.8 +/- 2.3%。在总治疗时间等于或长于 47 天的患者中，3 年和 5 年的局部控制率为 82.6 +/- 6.0%。在总治疗时间等于或小于46天的患者中，3年局部控制率为94.6+/-1.9%，5年局部控制率为91.8+/-2.4%。两组之间存在显着差异（P = 0.0349）。一名患者出现严重的晚期放射反应。放疗完成后 6 个月，他出现严重的喉部水肿，需要进行气管切开术。气管切开术在放疗完成后 14 个月时关闭。即使采用轻微的大分割治疗，总体治疗时间似乎也是声门 T1N0 癌良好局部控制率的重要因素。
We retrospectively investigated treatment outcomes in patients with glottic T1 carcinoma treated with 65 Gy in 26 fractions four times a week and discuss the importance of the overall treatment time.Two hundred one patients with glottic T1 carcinoma were evaluated. Sixty-five Gray in 26 fractions were delivered for 200 patients, whereas 1 patient received 62.5 Gy in 25 fractions. We delivered radiotherapy once daily four times a week in this period, for a weekly dose of 10 Gy. Weekdays except Wednesday were treatment days.The overall survival rate was 96.8 +/- 1.3% (standard error) at 3 years and 90.8 +/- 2.2% at 5 years. The local control rate was 91.9 +/- 2.0% at 3 years and 89.8 +/- 2.3% at 5 years. In patients with an overall treatment time equal to or longer than 47 days, the local control rate was 82.6 +/- 6.0% at both 3 and 5 years. In the patients with overall treatment time equal to or less than 46 days, the local control rate was 94.6 +/- 1.9% at 3 years and 91.8 +/- 2.4% at 5 years. There was a significant difference between these two groups (P = 0.0349). A severe late radiation reaction occurred in one patient. He experienced severe laryngeal edema that required tracheotomy at 6 months after the completion of radiotherapy. The tracheotomy was closed at 14 months after completion of radiotherapy.Overall treatment time seems to be an important factor for a good local control rate for glottic T1N0 carcinoma even when treated with slight hypofractionation.