Current concepts and techniques in keratoprosthesis.
Current concepts and techniques in keratoprosthesis.
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DOI：
10.1097/01.icu.0000172829.33770.d3
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发表时间：
2005-08-01
影响因子：
3.7
通讯作者：
Akpek, Esen Karamursel
中科院分区：
文献类型：
--
作者：
Ilhan-Sarac, Ozge;Akpek, Esen Karamursel
综述目的：在世界范围内，影响角膜的疾病是导致失明的主要原因，其总体重要性仅次于白内障，估计有1000万到1500万人受其影响。尽管角膜移植术是迄今为止最成功的移植手术，但在高危成年患者（包括患有眼表疾病和多次移植排斥的患者）以及患有先天性角膜混浊的儿童患者中，手术结果令人失望。
近期进展：遗憾的是，自从将类固醇用于移植排斥反应以来，角膜移植领域没有取得重大的临床进展。此外，获取供体角膜组织和眼库（尤其是在角膜盲最为普遍的发展中国家）存在问题。尽管术后并发症可能很严重，并限制了现有设备的使用，但角膜假体（人工角膜植入）在精心挑选的患有复杂眼病且移植失败风险高的角膜盲患者的治疗中具有一定作用。
总结：本文回顾了近期眼科文献中有关角膜假体手术的当前概念和技术。
PURPOSE OF REVIEW: Diseases affecting the cornea are a major cause of blindness worldwide, second only to cataract in overall importance, with an estimated 10 to 15 million affected people. Although keratoplasty is by far the most successful transplantation surgery, the outcomes in high-risk adult patients, including those with ocular surface diseases and multiple graft rejections, and in pediatric patients with congenital corneal opacities are disappointing.RECENT DEVELOPMENTS: Regrettably, no significant clinical developments have been achieved in the field of corneal transplantation since the introduction of steroids for graft rejection. Furthermore, obtaining donor corneal tissues and eye banking, particularly in the developing countries where corneal blindness is most prevalent, are problematic. Although the postoperative complications may be severe and limit the use of currently available devices, keratoprosthesis--artificial corneal implantation--has a role in the management of corneal blindness in carefully selected patients with complex ocular diseases who are at high risk for graft failure.SUMMARY: This article reviews the recent ophthalmic literature published on the current concepts and techniques of keratoprosthesis surgery.