Organization, evolution and functions of the human and mouse Ly6/uPAR family genes.
Organization, evolution and functions of the human and mouse Ly6/uPAR family genes.
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DOI：
10.1186/s40246-016-0074-2
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发表时间：
2016-04-21
期刊：
影响因子：
4.5
通讯作者：
Swamynathan SK
中科院分区：
文献类型：
--
作者：
Loughner CL;Bruford EA;McAndrews MS;Delp EE;Swamynathan S;Swamynathan SK
淋巴细胞抗原-6（Ly 6）/尿激酶型纤溶酶原激活物受体（uPAR）蛋白超家族成员是富含半胱氨酸的蛋白质，其特征在于形成三指Ly 6/uPAR（LU）结构域的独特二硫键模式。虽然Ly 6/uPAR家族蛋白具有共同的结构，但它们的表达模式和功能各不相同。迄今为止，已经鉴定了35个人类和61个小鼠Ly 6/uPAR家族成员。基于它们的亚细胞定位，这些蛋白质被进一步分类为GPI锚定在细胞膜上或分泌的。编码Ly 6/uPAR家族蛋白的基因在不同物种中是保守的，并且分别聚集在人染色体8、19、6和11以及小鼠染色体15、7、17和9上的同线区域中。在这里，我们回顾了人类和小鼠Ly 6/uPAR家族基因和蛋白质的结构和基因组的组织，表达，功能和进化，并介绍新的家庭成员的新名称。
Members of the lymphocyte antigen-6 (Ly6)/urokinase-type plasminogen activator receptor (uPAR) superfamily of proteins are cysteine-rich proteins characterized by a distinct disulfide bridge pattern that creates the three-finger Ly6/uPAR (LU) domain. Although the Ly6/uPAR family proteins share a common structure, their expression patterns and functions vary. To date, 35 human and 61 mouse Ly6/uPAR family members have been identified. Based on their subcellular localization, these proteins are further classified as GPI-anchored on the cell membrane, or secreted. The genes encoding Ly6/uPAR family proteins are conserved across different species and are clustered in syntenic regions on human chromosomes 8, 19, 6 and 11, and mouse Chromosomes 15, 7, 17, and 9, respectively. Here, we review the human and mouse Ly6/uPAR family gene and protein structure and genomic organization, expression, functions, and evolution, and introduce new names for novel family members.