Risk of thyroid follicular adenoma among children and adolescents in Belarus exposed to iodine-131 after the Chornobyl accident.
Risk of thyroid follicular adenoma among children and adolescents in Belarus exposed to iodine-131 after the Chornobyl accident.
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切尔诺贝利事故后白俄罗斯儿童和青少年接触碘 131 后患甲状腺滤泡腺瘤的风险。
DOI：
10.1093/aje/kwv127
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发表时间：
2015
影响因子：
5
通讯作者：
Minenko,Vik
中科院分区：
文献类型：
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作者：
Zablotska,LydiaB;Nadyrov,EldarA;Polyanskaya,OlgaN;McConnell,RobertJ;O'Kane,Patrick;Lubin,Jay;Hatch,Maureen;Little,MarkP;Brenner,AlinaV;Veyalkin,IlyaV;Yauseyenka,VasilinaV;Bouville,Andre;Drozdovitch,VladimirV;Minenko,Vik
多项研究报告称，1986 年切尔诺贝利（乌克兰语拼写）核电站事故后，接触放射性碘（主要是碘 131 (131I)）的儿童和青少年患甲状腺癌的风险增加。此类辐射暴露后发生良性甲状腺肿瘤的风险却鲜为人知。我们之前曾报道过一项新发现，在对乌克兰暴露于切尔诺贝利辐射尘埃的儿童和青少年进行的筛查研究中，甲状腺滤泡腺瘤的风险显着增加。为了验证这一发现，我们分析了白俄罗斯事故发生时年龄≤18岁的 11,613 名个体的基线筛查数据（筛查时的平均年龄 = 21 岁）。所有参与者均根据甲状腺放射性测量估算了个人 131I 剂量，并根据标准化方案进行了筛查。我们发现 38 例经病理证实的滤泡性腺瘤病例存在显着的线性剂量反应。每格雷的超额优势比为 2.22（95% 置信区间：0.41、13.1），男性和女性相似，但随着暴露年龄的增加而显着下降（P<0.01），估计暴露年龄 <2 岁的儿童的辐射风险最高。过去和当前碘缺乏的大多数指标并未显着改变滤泡性腺瘤的辐射风险。本研究证实乌克兰人群中与 131I 相关的滤泡性腺瘤风险增加，并增加了风险随着接触年龄降低而增加的新证据。
Several studies reported an increased risk of thyroid cancer in children and adolescents exposed to radioactive iodines, chiefly iodine-131 (131I), after the 1986 Chornobyl (Ukrainian spelling) nuclear power plant accident. The risk of benign thyroid tumors following such radiation exposure is much less well known. We have previously reported a novel finding of significantly increased risk of thyroid follicular adenoma in a screening study of children and adolescents exposed to the Chornobyl fallout in Ukraine. To verify this finding, we analyzed baseline screening data from a cohort of 11,613 individuals aged ≤18 years at the time of the accident in Belarus (mean age at screening = 21 years). All participants had individual131I doses estimated from thyroid radioactivity measurements and were screened according to a standardized protocol. We found a significant linear dose response for 38 pathologically confirmed follicular adenoma cases. The excess odds ratio per gray of 2.22 (95% confidence interval: 0.41, 13.1) was similar in males and females but decreased significantly with increasing age at exposure (P< 0.01), with the highest radiation risks estimated for those exposed at <2 years of age. Follicular adenoma radiation risks were not significantly modified by most indicators of past and current iodine deficiency. The present study confirms the131I-associated increases in risk of follicular adenoma in the Ukrainian population and adds new evidence on the risk increasing with decreasing age at exposure.