An unusual ostensible example of intraoral basal cell carcinoma
An unusual ostensible example of intraoral basal cell carcinoma
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口腔内基底细胞癌的一个不寻常的表面例子
DOI：
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发表时间：
2009
影响因子：
1.7
通讯作者：
A. Vortmeyer
中科院分区：
文献类型：
--
作者：
I. Koutlas;C. Koch;R. Vickers;F. M. Brouwers;A. Vortmeyer
口腔基底细胞癌的一个例子是提出起源于后下颌粘膜和牙龈的67岁的女性。在组织学上，它具有多灶性模式。在20年的时间里复发了8次。 用单克隆抗体Ber-EP 4评价肿瘤组织样本，并与口腔粘膜、皮肤、口腔和皮肤鳞状细胞癌、外周性成釉细胞瘤、成釉细胞瘤和皮肤基底细胞癌（BCC）的样本进行比较。仅肿瘤性基底细胞免疫组化染色阳性。此外，用标记物D9 S303、D9 S252和D9 S287评价显微切割的肿瘤区域的PTCH基因杂合性缺失（洛）。在Gorlin综合征和散发性皮肤基底细胞癌患者中报告了PTCH基因突变。所有三种标记均观察到一个等位基因丢失。常规成釉细胞瘤的例子没有显示出洛丢失的证据。这些观察结果支持纳入BCC的鉴别诊断适当的口腔粘膜肿瘤。
An example of oral basal cell carcinoma is presented originating on the posterior mandibular mucosa and gingiva of a 67‐year‐old female. Histologically, it featured a multifocal pattern. It recurred eight times in a period of 20 years. Tissue samples of the tumor were evaluated with monoclonal antibody Ber‐EP4 and were compared with examples of oral mucosa, skin, oral and cutaneous squamous cell carcinoma, peripheral ameloblastoma, ameloblastoma and cutaneous basal cell carcinoma (BCC). Only neoplastic basal cells showed positive immunohistochemical staining. Additionally, microdissected neoplastic areas were evaluated for loss of heterozygosity (LOH) of the PTCH gene with markers D9S303, D9S252 and D9S287. PTCH gene mutations are reported in patients with Gorlin syndrome and sporadic cutaneous BCCs. Loss of one allele was observed with all three markers. Examples of conventional ameloblastomas did not show evidence of LOH. These observations support the inclusion of BCC in the differential diagnosis of appropriate oral mucosal neoplasms.
细胞调节中的蛋白多糖。
DOI：
--
发表时间：
1989
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Ruoslahti,E
通讯作者：
Ruoslahti,E