Does smoking, age or gender affect the protein phenotype of extracellular vesicles in plasma?
Does smoking, age or gender affect the protein phenotype of extracellular vesicles in plasma?
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DOI：
10.1016/j.transci.2016.07.012
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发表时间：
2016-08-01
影响因子：
1.9
通讯作者：
Jorgensen, M. M.
中科院分区：
文献类型：
--
作者：
Baek, R.;Varming, K.;Jorgensen, M. M.
细胞外囊泡 (EV) 与多种疾病有关，这为 EV 分析在临床环境中的潜在应用奠定了基础。 EV 的蛋白质表型可以提供有关囊泡功能的信息，并可用于鉴定与疾病相关的生物标志物。这项对 161 名健康个体的广泛研究表明，血浆 EV 的某些标志物受到性别、年龄和吸烟状况等人口统计差异的影响。当目的是使用 EV 作为诊断工具时，应该强调在比较血浆 EV 标记水平时选择正确的人口群体是多么重要。 (C) 2016 年作者。由爱思唯尔有限公司出版
Extracellular vesicles (EVs) are involved in several diseases, which have formed the basis for the potential use of EV analyses in a clinical setting. The protein phenotype of EVs can provide information on the functionality of the vesicles and may be used for identification of disease-related biomarkers.With this extensive study of 161 healthy individuals it was elucidated that certain markers of plasma EVs are influenced by demographic variations such as gender, age and smoking status. When the purpose is to use EVs as a diagnostic tool, it should be emphasized how important it is to choose the correct demographic group when comparing marker levels of plasma EVs. (C) 2016 The Authors. Published by Elsevier Ltd.