Lantibiotics: How do producers become self-protected?
Lantibiotics: How do producers become self-protected?
复制标题
DOI：
10.1016/j.jbiotec.2012.01.032
复制
发表时间：
2012-06-15
影响因子：
4.1
通讯作者：
Smits, Sander H. J.
中科院分区：
文献类型：
--
作者：
Alkhatib, Zainab;Abts, Andre;Smits, Sander H. J.
羊毛硫抗生素是由革兰氏阳性菌产生的小肽，其作为前肽通过核糖体合成。它们的基因高度组织在操纵子中，包含成熟、运输、免疫和合成所需的所有基因。特征最好的羊毛硫抗生素是来自乳酸乳球菌的乳链菌肽。乳链菌肽通过各种作用模式对其他革兰氏阳性菌具有活性。为了防止针对其生产菌株的活性，已经开发了由不同蛋白质组成的自身免疫系统，ABC转运蛋白NisFEG和膜锚定蛋白NisI。它们共同阻止乳链菌肽发挥作用并导致乳酸链球菌细胞死亡。乳酸菌。在这篇综述中，将讨论免疫机制的调节、生物合成和活性的机制。并简要介绍了这些免疫蛋白在医学和工业领域的应用。(C)2012爱思唯尔有限公司版权所有。
Lantibiotics are small peptides produced by Gram-positive bacteria, which are ribosomally synthesized as a prepeptide. Their genes are highly organized in operons containing all the genes required for maturation, transport, immunity and synthesis. The best-characterized lantibiotic is nisin from Lactococcus lactis. Nisin is active against other Gram-positive bacteria via various modes of actions. To prevent activity against its producer strain, an autoimmunity system has developed consisting of different proteins, the ABC transporter NisFEG and a membrane anchored protein NisI. Together, they circumvent the ability of nisin to fulfill its action and cause cell death of L. lactis. Within this review, the mechanism of regulation, biosynthesis and activity of the immunity machinery will be discussed. Furthermore a short description about the application of these immunity proteins in both medical and industrial fields is highlighted. (C) 2012 Elsevier B.V. All rights reserved.