A cross-sectional analysis of association between visceral adiposity index and serum anti-aging protein Klotho in adults.
A cross-sectional analysis of association between visceral adiposity index and serum anti-aging protein Klotho in adults.
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DOI：
10.3389/fendo.2023.1082504
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发表时间：
2023
影响因子：
5.2
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中科院分区：
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内脏脂肪指数（VAI）被认为是评价体脂分布和功能障碍的可靠指标。Klotho蛋白是一种具有抗衰老生物学功能的激素。然而，它们之间的关系尚未被研究。本研究旨在评估美国成年人VAI与血清抗衰老蛋白Klotho之间的相关性。根据2007-2016年国家健康和营养检查调查（NHANES）对参与者进行了横断面研究。内脏肥胖使用VAI评分确定，而klotho蛋白浓度通过ELISA试剂盒测量。在调整一些可能的混杂变量后，通过多变量回归模型估计VAI和klotho蛋白之间的关系。此外，还采用平滑曲线拟合和分段回归模型来检验阈值效应和计算拐点。总共有6252名成人合格，平均VAI为2.04 ± 0.03，平均klotho蛋白浓度为848.79 ± 6.98 pg/ml。多元回归分析表明，血清klotho蛋白浓度较低的参与者与高VAI评分。当将VAI分为四分位数时，在完全调整后，较高VAI的第四四个四分位数的参与者的klotho蛋白水平（Q4：-32.25 pg/ml）低于最低四分位数（Q1）的参与者（P < 0.05）。分段回归分析表明VAI的转折点值为3.21。VAI每增加1个单位，klotho蛋白水平降低-18.61 pg/ml（95% CI：-28.87，-8.35;当VAI在0.29 ~ 3.21之间时，P < 0.05（占参与者的83.7%），然而，当VAI在3.21至11.81之间时，相关性不显著（P = 0.77）。VAI评分与血清抗衰老蛋白klotho浓度呈非线性相关，呈饱和效应。当VAI小于3.21时，两者呈负相关，当VAI大于3.21时，两者无明显相关性。
The visceral adiposity index (VAI) is regarded as a reliable indicator to assess body fat distribution and dysfunction. Klotho protein is a hormone with anti-aging biological functions. However, the relationship between them has not been researched. This study aimed to evaluate the association between VAI and serum anti-aging protein klotho in American adults. A cross-sectional study of participants was conducted based on the National Health and Nutrition Examination Surveys (NHANES) 2007–2016. Visceral adiposity was determined using the VAI score, while the klotho protein concentration was measured by ELISA kit. After adjusting some possible confounding variables, multivariate regression model was conducted to estimate the relationship between VAI and klotho protein. Furthermore, the smooth curve fitting and the segmented regression model were applied to examine the threshold effect and to calculate the inflection point. In total, 6 252 adults were eligible, with a mean VAI of 2.04 ± 0.03 and a mean klotho protein concentration of 848.79 ± 6.98 pg/ml. Multivariate regression analysis indicated that serum klotho protein concentration was lower in participants with high VAI score. When VAI was divided into quartiles, participants in the fourth quartiles of higher VAI had lower klotho protein levels (Q4: -32.25 pg/ml) than participants in the lowest quartile (Q1) after full adjustment (P < 0.05). Segmented regression suggested that the turning point value of VAI was 3.21. A 1-unit increase in VAI was significantly associated with lower klotho protein levels by -18.61 pg/ml (95% CI: -28.87, -8.35; P < 0.05) when VAI ranged from 0.29 to 3.21(accounting for 83.7% of the participants), however, the association was not significant when VAI ranged from 3.21 to 11.81 (P = 0.77). There was a nonlinear correlation between VAI score and the serum anti-aging protein klotho concentrations, showing a saturation effect. When VAI was less than 3.21, they were negatively correlated, and when VAI was greater than 3.21, they had no obvious correlation.