Industrial hygiene assessment of reticuloendotheliosis viruses exposure in the poultry industry.
Industrial hygiene assessment of reticuloendotheliosis viruses exposure in the poultry industry.
复制标题
家禽业中网状内皮增生病毒暴露的工业卫生评估。
DOI：
10.1007/s00420-010-0578-3
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发表时间：
2011
影响因子：
3
通讯作者：
Johnson,EricS
中科院分区：
文献类型：
--
作者：
Choi,Kyung-Mee;Johnson,EricS
目的网状内皮组织增生病病毒（Reticuloendotheliosis viruses，REV）是一组与禽白血病/肉瘤病毒（avian leukosis/sarcoma viruses，ALSV）相似的逆转录病毒，可自然感染鸡并引起鸡的恶性肿瘤。我们最近发现ALSV抗体水平与家禽业的工作任务有关。本研究的目的是检查是否可以发现类似的关联与REV抗体水平，并检查REV和ALSV抗体levels.MethodsRelative风险之间的相关性估计比较REV抗体水平的45个家禽工人与44个控制。预期的平均抗体水平预测与就业的广义线性模型。ALSV和REV抗体水平之间的相关系数测定resultsreV抗体水平显着高于对照组，家禽工人，并与性别和就业条件，特别是就业时间。某些工作类别的相对风险明显更高。REV和ALSV抗体水平之间观察到显着的相关性，这是强家禽工人，但弱之间的控制subjects.ConclusionAntibody水平可以有效地用来确定某些工作任务与高风险的REV暴露在工作场所，和实际意义是在这些工作任务的保护建议。重要的是，在工作场所暴露于多种病原体的情况下，对一种病原体的抗体水平的分析可能足以代表对其他相关病原体的暴露。这一建议的暴露评估可能适用于具有类似传播途径的病原体。
ObjectivesReticuloendotheliosis viruses (REV) are a group of retroviruses like avian leukosis/sarcoma viruses (ALSV) that naturally infect and cause cancers in chickens. We recently found that ALSV antibody levels were associated with job tasks in the poultry industry. The objectives of this study are to examine whether a similar association can be found with REV antibody levels and to examine the correlation between REV and ALSV antibody levels.MethodsRelative risk was estimated comparing REV antibody levels of 45 poultry workers with those of 44 controls. The expected mean antibody level was predicted for the association with employment by a generalized linear model. Correlation coefficient was measured between ALSV and REV antibody levels.ResultsREV antibody levels were significantly higher in poultry workers than in control subjects and were associated with gender and employment conditions, especially employment duration. The relative risk was significantly higher for some job categories. A significant correlation was observed between REV and ALSV antibody levels, which was strong among poultry workers, but weak among the control subjects.ConclusionAntibody levels can be validly used to identify certain job tasks associated with high risk of exposure to REV in the workplace, and the practical implication is recommendations for protection at these job tasks. Importantly, in situations where there is exposure to multiple pathogens in the workplace, the analysis of antibody levels of one pathogen may sufficiently represent exposure to the other correlated pathogens. This suggested exposure assessment may hold true for pathogens with a similar route of transmission.