High-Frequency Oscillations in the Normal Human Brain
High-Frequency Oscillations in the Normal Human Brain
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DOI：
10.1002/ana.25304
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发表时间：
2018-09-01
影响因子：
11.2
通讯作者：
Gotman, Jean
中科院分区：
文献类型：
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作者：
Frauscher, Birgit;von Ellenrieder, Nicolas;Gotman, Jean
高频振荡（HFO）是一种有前途的致痫区生物标志物。然而，尚不可能区分生理性和病理性HFO，并且HFO发生的基线率在脑区域之间差异很大。该项目建立了特定区域的生理HFO和高频活动（HFA）的标准值。MethodsIntracerebral stereographic recordings与通道显示正常的生理活动从nonlesional组织从2个三级癫痫中心。选择N2/N3睡眠的20分钟部分用于自动检测波纹（80- 250 Hz）、快速波纹（> 250 Hz）和HFA（定义为> 80 Hz的持久活动）。提供了17个脑regions.ResultsA共1,171双极通道与正常的生理活动从71例进行了分析。波动率最高的记录在枕叶皮质，内侧和基底颞区，颞横回和颞平面，前和后中央回，内侧顶叶。快速波动的平均速率非常低（0.038/min）。只有5%的通道有一个率> 0.2/min HFA被观察到在内侧枕叶，前和后中央回，颞横回和颞平面，和外侧枕loba.InterpretationThis多中心图集是第一个提供区域特异性的生理HFO率和HFA在共同的立体定向空间的标准值;率高于这些现在可以被认为是病理。在功能皮层中经常出现生理波动。相比之下，生理性快速波动非常罕见，使得快速波动成为定义致痫区的良好候选者。神经学年鉴2018;84：374-385
ObjectiveHigh-frequency oscillations (HFOs) are a promising biomarker for the epileptogenic zone. It has not been possible, however, to differentiate physiological from pathological HFOs, and baseline rates of HFO occurrence vary substantially across brain regions. This project establishes region-specific normative values for physiological HFOs and high-frequency activity (HFA).MethodsIntracerebral stereo-encephalographic recordings with channels displaying normal physiological activity from nonlesional tissue were selected from 2 tertiary epilepsy centers. Twenty-minute sections from N2/N3 sleep were selected for automatic detection of ripples (80-250Hz), fast ripples (>250Hz), and HFA defined as long-lasting activity > 80Hz. Normative values are provided for 17 brain regions.ResultsA total of 1,171 bipolar channels with normal physiological activity from 71 patients were analyzed. The highest rates of ripples were recorded in the occipital cortex, medial and basal temporal region, transverse temporal gyrus and planum temporale, pre- and postcentral gyri, and medial parietal lobe. The mean rate of fast ripples was very low (0.038/min). Only 5% of channels had a rate > 0.2/min HFA was observed in the medial occipital lobe, pre- and postcentral gyri, transverse temporal gyri and planum temporale, and lateral occipital lobe.InterpretationThis multicenter atlas is the first to provide region-specific normative values for physiological HFO rates and HFA in common stereotactic space; rates above these can now be considered pathological. Physiological ripples are frequent in eloquent cortex. In contrast, physiological fast ripples are very rare, making fast ripples a good candidate for defining the epileptogenic zone. Ann Neurol 2018;84:374-385