Salivary bisphenol-A levels detected by ELISA after restoration with composite resin
Salivary bisphenol-A levels detected by ELISA after restoration with composite resin
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DOI：
10.1007/s10856-005-0627-8
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发表时间：
2005-04-01
影响因子：
3.7
通讯作者：
Kubono, K
中科院分区：
文献类型：
--
作者：
Sasaki, N;Okuda, K;Kubono, K
双酚-A二缩水甘油醚甲基丙烯酸酯(Bis-GMA)是由具有外源性内分泌干扰作用的化合物双酚-A(BPA)合成的，被广泛用作牙科材料。在临床填充密封剂和复合树脂的过程中，通过聚合将化合物固化，然后使用。然而，人们已经注意到，未聚合的单体可能会溶解在唾液中。本研究采用竞争性ELISA法，研究了复合树脂修复后唾液中双酚A浓度的变化。对来自9家公司的商用复合树脂进行了测试。采集21例受试者的混合唾液。根据该系统检测唾液中双酚A的动态变化，我们得出结论：用复合树脂充填牙齿后，唾液中含有几十到100 ng/ml的双酚A，但只要足够的含漱量就可以将其从口腔中去除。我们的数据表明，治疗后足够的漱口对风险管理很重要。(C)2005年Springer Science+Business Media，Inc.
Bisphenol-A diglycidylether methacrylate (Bis-GMA), which is synthesized from bisphenol-A (BPA), a compound with exogenous endocrine disrupter action, is widely used as a dental material. During clinical filling with sealants and composite resins, the compounds are solidified by polymerization and then used. However, it has been noted that unpolymerized monomers may become dissolved in saliva. In this study using a competitive ELISA system, we investigated the changes in the BPA concentration in saliva after restoration with composite resins. Commercial composite resins from nine companies were tested. Mixed saliva was collected from 21 subjects. Based on the dynamics of salivary BPA detected by this ELISA system, we concluded that several tens to 100 ng/ml of BPA were contained in saliva after filling teeth with composite resin but that sufficient gargling can remove it from the oral cavity. Our data suggest that sufficient gargling after treatment is important for risk management. (C) 2005 Springer Science + Business Media, Inc.