Photomagnetic Prussian blue nanocubes: Synthesis, characterization, and biomedical applications
Photomagnetic Prussian blue nanocubes: Synthesis, characterization, and biomedical applications
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DOI：
10.1016/j.nano.2019.102138
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发表时间：
2020-02-01
影响因子：
5.4
通讯作者：
Emelianov, Stanislav Y.
中科院分区：
文献类型：
--
作者：
Dumani, Diego S.;Cook, Jason R.;Emelianov, Stanislav Y.
纳米粒子在生物医学中发挥着重要作用。我们开发了一种使用超顺磁性氧化铁纳米颗粒（SPION）作为前体来控制尺寸合成光磁性普鲁士蓝纳米立方体（PBNC）的方法。开发的 PBNC 具有许多生物医学诊断和治疗应用所需的磁性和光学特性。具体来说，尺寸可调的光磁PBNC表现出高磁饱和度、强光吸收（峰值约为700 nm）和优异的光稳定性。我们的研究表明，PBNC 可用作体内 MRI 和光声成像造影剂。我们还展示了 PBNC 在细胞标记和磁性操作方面的实用性。磁性和光学双重特性以及出色的生物相容性使 PBNC 成为诊断和治疗应用中极具吸引力的造影剂。使用 SPION 作为 PBNC 的前体提供了灵活性，并允许研究人员根据所需的粒径、光学和磁性特性设计治疗诊断剂。 (C) 2019 Elsevier Inc. 保留所有权利。
Nanoparticles play an important role in biomedicine. We have developed a method for size-controlled synthesis of photomagnetic Prussian blue nanocubes (PBNCs) using superparamagnetic iron oxide nanoparticles (SPIONs) as precursors. The developed PBNCs have magnetic and optical properties desired in many biomedical diagnostic and therapeutic applications. Specifically, the size-tunable photomagnetic PBNCs exhibit high magnetic saturation, strong optical absorption with a peak at approximately 700 nm, and superior photostability. Our studies demonstrate that PBNCs can be used as MRI and photoacoustic imaging contrast agents in vivo. We also showed the utility of PBNCs for labeling and magnetic manipulation of cells. Dual magnetic and optical properties, together with excellent biocompatibility, render PBNCs an attractive contrast agent for both diagnostic and therapeutic applications. The use SPIONs as precursors for PBNCs provides flexibility and allows researchers to design theranostic agents according to required particle size, optical, and magnetic properties. (C) 2019 Elsevier Inc. All rights reserved.