An X-Linked Haplotype of Neandertal Origin Is Present Among All Non-African Populations
An X-Linked Haplotype of Neandertal Origin Is Present Among All Non-African Populations
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DOI：
10.1093/molbev/msr024
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发表时间：
2011-07-01
影响因子：
10.7
通讯作者：
Labuda, Damian
中科院分区：
文献类型：
--
作者：
Yotova, Vania;Lefebvre, Jean-Francois;Labuda, Damian
最近对尼安德特人基因组的研究提出了尼安德特人和不断扩大的智人之间混合的可能性，智人在80到50 Kya（千年前）之间离开非洲殖民世界其他地区。在这里，我们提供了一个显着的存在（9%的整体）的尼安德特人来源的X染色体片段在非洲以外的所有当代人群的证据。我们对来自所有有人居住的大陆的6，092条X染色体的分析支持了早期的论点，即不同时间深度和不同地理起源的谱系马赛克可能有助于现代人类的遗传构成。它表明，在非洲以外的扩张之前或非常早期，非洲移民和尼安德特人之间的早期混合导致了地球的成功殖民化。
Recent work on the Neandertal genome has raised the possibility of admixture between Neandertals and the expanding population of Homo sapiens who left Africa between 80 and 50 Kya (thousand years ago) to colonize the rest of the world. Here, we provide evidence of a notable presence (9% overall) of a Neandertal-derived X chromosome segment among all contemporary human populations outside Africa. Our analysis of 6,092 X-chromosomes from all inhabited continents supports earlier contentions that a mosaic of lineages of different time depths and different geographic provenance could have contributed to the genetic constitution of modern humans. It indicates a very early admixture between expanding African migrants and Neandertals prior to or very early on the route of the out-of-Africa expansion that led to the successful colonization of the planet.