Neurological Disorders and Risk of Arrhythmia.
Neurological Disorders and Risk of Arrhythmia.
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DOI：
10.3390/ijms22010188
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发表时间：
2020-12-27
影响因子：
5.6
通讯作者：
Aromolaran AS
中科院分区：
文献类型：
--
作者：
Bernardi J;Aromolaran KA;Aromolaran AS
包括抑郁、焦虑、创伤后应激障碍（PTSD）、精神分裂症、自闭症和癫痫在内的神经系统疾病与心血管疾病发病率增加和心力衰竭易感性相关。神经系统疾病和不良心功能之间的潜在分子机制尚不清楚。此外，缺乏进展可能是由于缺乏调查健康和疾病中神经障碍与心脏电活动之间关系的研究。因此，有一个重要的需要了解神经心脏机制的时空行为。这可以通过识别和验证可能受到不利调节的神经和心脏信号通路来推进。在这篇综述中，我们强调了下丘脑-垂体-肾上腺（HPA）轴功能障碍、自主神经系统（ANS）活动和炎症是如何导致精神疾病和心功能障碍的。此外，抗精神病药物和抗抑郁药物增加了心脏不良事件的风险，主要是通过阻断人类以太-a- a-go-go相关基因（hERG），该基因在心脏复极中起关键作用。因此，了解神经系统疾病如何导致不良的心脏离子通道重构可能对开发有效的治疗干预措施具有重要意义，并有助于改善具有重要临床意义的靶向治疗方法的合理开发。
Neurological disorders including depression, anxiety, post-traumatic stress disorder (PTSD), schizophrenia, autism and epilepsy are associated with an increased incidence of cardiovascular disorders and susceptibility to heart failure. The underlying molecular mechanisms that link neurological disorders and adverse cardiac function are poorly understood. Further, a lack of progress is likely due to a paucity of studies that investigate the relationship between neurological disorders and cardiac electrical activity in health and disease. Therefore, there is an important need to understand the spatiotemporal behavior of neurocardiac mechanisms. This can be advanced through the identification and validation of neurological and cardiac signaling pathways that may be adversely regulated. In this review we highlight how dysfunction of the hypothalamic–pituitary–adrenal (HPA) axis, autonomic nervous system (ANS) activity and inflammation, predispose to psychiatric disorders and cardiac dysfunction. Moreover, antipsychotic and antidepressant medications increase the risk for adverse cardiac events, mostly through the block of the human ether-a-go-go-related gene (hERG), which plays a critical role in cardiac repolarization. Therefore, understanding how neurological disorders lead to adverse cardiac ion channel remodeling is likely to have significant implications for the development of effective therapeutic interventions and helps improve the rational development of targeted therapeutics with significant clinical implications.
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作者：
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