Klotho, the Key to Healthy Brain Aging?
Klotho, the Key to Healthy Brain Aging?
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DOI：
10.3233/bpl-170057
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发表时间：
2018-08-10
期刊：
影响因子：
--
通讯作者：
King GD
中科院分区：
文献类型：
--
作者：
Vo HT;Laszczyk AM;King GD
klotho 基因的最初发现首次描述了 klotho 的大脑表达。 Klotho 显着的年龄调节作用归因于通过肾脏中的 Klotho 功能调节离子稳态。然而，最近的进展确定了大脑功能和细胞群，包括成人海马神经祖细胞，它们需要 klotho。此外，人类相关研究和小鼠疾病模型都表明，klotho 可以预防多种神经和心理疾病。这篇综述重点关注有关 klotho 蛋白如何影响大脑的当前知识。
Brain expression of klotho was first described with the initial discovery of the klotho gene. The prominent age-regulating effects of klotho are attributed to regulation of ion homeostasis through klotho function in the kidney. However, recent advances identified brain functions and cell populations, including adult hippocampal neural progenitors, which require klotho. As well, both human correlational studies and mouse models of disease show that klotho is protective against multiple neurological and psychological disorders. This review focuses on current knowledge as to how the klotho protein effects the brain.