Neuronal degeneration in locus ceruleus and cortical correlates of Alzheimer disease.
Neuronal degeneration in locus ceruleus and cortical correlates of Alzheimer disease.
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DOI：
10.1097/00002093-198701040-00005
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发表时间：
1987-01-01
影响因子：
2.1
通讯作者：
Hauser, D L
中科院分区：
文献类型：
--
作者：
Bondareff, W;Mountjoy, C Q;Hauser, D L
研究了中枢去肾上腺素能损伤参数蓝核座（nLC）神经元变性与阿尔茨海默病（AD）新皮质标志物之间的关系。nLC神经元的损失与去甲肾上腺素浓度、胆碱乙酰转移酶（ChAT）活性、Brodmann区24（扣带回）斑块和缠结数量显著相关；颞区21区ChAT和斑块计数；10区（额叶）ChAT活动。此外，nLC神经元计数与痴呆的严重程度和估计持续时间显著相关。nLC中神经原纤维缠结的数量与阿尔茨海默病的新皮层标志物没有显著相关性，但与痴呆症的估计持续时间和严重程度相关。这些数据提示中枢去肾上腺素能通路的改变与AD的病理生理有关。
Relationships were examined between neuronal degeneration in the nucleus locus ceruleus (nLC), a parameter of central noradrenergic impairment, and neocortical markers of Alzheimer disease (AD). The loss of nLC neurons was found to correlate significantly with norepinephrine concentration, choline acetyltransferase (ChAT) activity, and numbers of plaques and tangles on Brodmann area 24 (cingulate); ChAT and plaque counts in area 21 (temporal); and with ChAT activity in area 10 (frontal). In addition, nLC neuronal counts were correlated significantly with the severity and estimated duration of dementia. The number of neurofibrillary tangles in nLC, which did not correlate significantly with neocortical markers of AD, correlated with the estimated duration and severity of dementia. These data suggest that changes in central noradrenergic pathways are related to the pathophysiology of AD.