Family size, day-care attendance, and breastfeeding in relation to the incidence of childhood asthma
Family size, day-care attendance, and breastfeeding in relation to the incidence of childhood asthma
复制标题
DOI：
10.1093/aje/153.7.653
复制
发表时间：
2001-04-01
影响因子：
5
通讯作者：
Malo, JL
中科院分区：
文献类型：
--
作者：
Infante-Rivard, C;Amre, D;Malo, JL
有人提出一种假说，认为儿童早期接触感染的可能性较小，不太可能发展为特应性或哮喘。作者调查了儿童哮喘风险与兄弟姐妹数量以及日托出勤率之间的关系，这些因素可能会增加早期感染的可能性，而母乳喂养则是降低这些可能性的因素。1988年至1995年在加拿大蒙特利尔进行了一项病例对照研究，其中包括457名3-4岁诊断为哮喘的儿童和457名健康对照。随访6年的病例在诊断后根据症状和药物使用情况分为持续性或短暂性。在3-4岁诊断的病例中。一个兄弟姐妹哮喘的校正优势比为0.54（95%可信区间（CI）：0.36，0.80），两个或更多兄弟姐妹哮喘的校正优势比为0.49（95% CI：0.30，0.81）。1岁之前日托出勤率的调整优势比为0.59（95%CI：0.40，0.87）。结果与持续性病例相似。在短暂的病例中（可能在3-4岁时感染喘息），日托和母乳喂养时间短导致风险增加，结果支持早期感染机会降低哮喘风险的假设。
A hypothesis has been suggested stating that children exposed early to infections are less likely to develop atopy or asthma. The authors investigated the relation between risk of childhood asthma and number of siblings as well as day-care attendance, as factors possibly increasing the likelihood of early infections, and breastfeeding as a factor reducing them. A case-control study was carried out in Montreal, Canada, between 1988 and 1995 that included 457 children diagnosed with asthma at 3-4 years of age and 457 healthy controls. Cases followed for 6 years were later classified as persistent or transient by the symptoms and use of medication after diagnosis. Among cases diagnosed at 3-4 years of age. the adjusted odds ratio for asthma was 0.54 (95% confidence interval (CI): 0,36, 0.80) for one sibling and 0.49 (95% CI: 0.30, 0.81) for two or more. The adjusted odds ratio for day-care attendance before 1 year of age was 0.59 (95% CI: 0.40, 0.87). Results were similar with persistent cases. Among transient cases (who possibly had an infection with wheezing at 3-4 years of age), daycare attendance and a short duration of breastfeeding resulted in increased risk, The results support the hypothesis that opportunity for early infections reduces the risk of asthma.