Formation of Supramolecular Nanostructures through in Situ Self‐Assembly and Post‐Assembly Modification of a Biocatalytically Constructed Dipeptide Hydrazide
Formation of Supramolecular Nanostructures through in Situ Self‐Assembly and Post‐Assembly Modification of a Biocatalytically Constructed Dipeptide Hydrazide
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通过生物催化构建的二肽酰肼的原位自组装和组装后修饰形成超分子纳米结构
DOI：
10.1002/chem.202104421
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Ikeda Masato
中科院分区：
文献类型：
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作者：
Shintani Yuki;Ohtomi Taku;Shibata Aya;Kitamura Yoshiaki;Hirosawa Koichiro M.;Suzuki Kenichi G. N.;Ikeda Masato
短肽的水溶液自组装在构建各种生物应用的超分子材料方面引起了越来越多的关注。在本文中，我们描述了嗜热菌蛋白酶辅助的由N-保护的氨基酸和氨基酸酰肼的二肽酰肼的生物催化构建如何导致热稳定的超分子水凝胶的形成。此外，我们证明了组装后修饰的超分子结构构建在原位栓系酰肼基团作为化学处理通过荧光成像。
Aqueous self‐assembly of short peptides has attracted growing attention for the construction of supramolecular materials for various bioapplications. Herein, we describe how the thermolysin‐assisted biocatalytic construction of a dipeptide hydrazide from an N‐protected amino acid and an amino acid hydrazide leads to the formation of thermally stable supramolecular hydrogels. In addition, we demonstrate the post‐assembly modification of the supramolecular architectures constructed in situ tethering hydrazide groups as a chemical handle by means of fluorescence imaging.