Feasibility and preliminary efficacy of acupuncture for angina in an underserved diverse population.
Feasibility and preliminary efficacy of acupuncture for angina in an underserved diverse population.
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DOI：
10.1177/09645284211055754
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发表时间：
2022-04
期刊：
影响因子：
--
通讯作者：
Schlaeger JM
中科院分区：
文献类型：
--
作者：
DeVon HA;Uwizeye G;Cai HY;Shroff AR;Briller JE;Ardati A;Hoppensteadt D;Rountree L;Schlaeger JM
稳定型心绞痛是运动或情绪紧张时的缺血性胸痛。尽管有指南指导的治疗，高达30%的患者疼痛缓解效果不佳。本研究的目的是：（1）确定针灸随机对照试验（RCT）的可行性和可接受性;（2）评估针灸在减轻疼痛和提高功能状态以及健康相关生活质量（HRQoL）方面的初步疗效。稳定型心绞痛患者接受标准化针灸方案（每周两次，持续5周）或注意力控制方案。测量指标包括麦吉尔疼痛问卷（平均疼痛强度（API），疼痛现在）和西雅图心绞痛问卷-7（功能状态，症状和HRQoL）。可行性定义为招募率为80%，入组后保留率为75%，完成率为80%。采用描述性统计和混合效应线性回归进行分析。样本（n = 24）的平均年龄为59 ± 12岁，主要为女性（63%），代表少数群体（8%白色、52%黑人、33%西班牙裔和8%其他）。79%的保留率和89%的完成率支持可行性。招聘率（68%）略低于预期。针刺组和对照组的可接受性评分分别为87.9%和51.7%。针刺组的结果明显优于对照组（API，B =-2.1（1.1），p = 0.047;功能状态，B = 27.6（7.2），p < 0.001; HRQoL，B = 38.8（11.9），p = 0.001）。针灸在我们多样化的样本中是可行和可接受的。我们略低于80%的招募目标，但开始研究的参与者完成研究的可能性很高。针灸对稳定型心绞痛有希望，但其有效性需要通过更大的、有足够把握的随机对照试验来证实。NCT 02914834（ClinicalTrials.gov）。
Stable angina is ischemic chest pain on exertion or with emotional stress. Despite guideline-directed therapy, up to 30% of patients have suboptimal pain relief. The aims of this study were to: (1) determine the feasibility and acceptability of a randomized controlled trial (RCT) of acupuncture; and (2) evaluate preliminary efficacy of acupuncture with respect to reduction of pain and increased functional status and health-related quality of life (HRQoL). Participants with stable angina for ⩾1 month received either a standardized acupuncture protocol, twice per week for 5 weeks, or an attention control protocol. Measures included the McGill Pain Questionnaire (average pain intensity (API), pain now) and the Seattle Angina Questionnaire–7 (functional status, symptoms, and HRQoL). Feasibility was defined as ⩾80% recruitment, ⩾75% retention following enrollment, and ⩾80% completion. Descriptive statistics and mixed-effects linear regression were used for analysis. The sample (n = 24) had a mean age of 59 ± 12 years, was predominantly female (63%), and represented minority groups (8% White, 52% Black, 33% Hispanic, and 8% Other). Feasibility was supported by 79% retention and 89% completion rates. The recruitment rate (68%) was slightly lower than expected. Acceptability scores were 87.9% for the acupuncture group and 51.7% for the control group. Outcomes were significantly better for the acupuncture versus control groups (API, b = −2.1 (1.1), p = 0.047; functional status, b = 27.6 (7.2), p < 0.001; and HRQoL, b = 38.8 (11.9), p = 0.001). Acupuncture was feasible and acceptable in our diverse sample. We were slightly under the recruitment target of 80%, but participants who started the study had a high likelihood of completing it. Acupuncture shows promise for stable angina, but its effectiveness needs to be confirmed by a larger, adequately powered RCT. NCT02914834 (ClinicalTrials.gov).
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影响因子：
5.7
作者：
Harris, Richard E.;Zubieta, Jon-Kar;Scott, David J.;Napadow, Vitaly;Gracely, Richard H.;Clauw, Daniel J.
通讯作者：
Clauw, Daniel J.
影响因子：
24
作者：
Fihn, Stephan D.;Gardin, Julius M.;Yancy, Clyde W.
通讯作者：
Yancy, Clyde W.
影响因子：
2.8
作者：
DeVon, Holli A.;Burke, Larisa A.;Riley, Barth
通讯作者：
Riley, Barth
DOI：
10.1161/circoutcomes.114.000967
发表时间：
2014-09
期刊：
Circulation. Cardiovascular quality and outcomes
影响因子：
--
作者：
Chan PS;Jones PG;Arnold SA;Spertus JA
通讯作者：
Spertus JA
影响因子：
11.1
作者：
BALLEGAARD, S;PEDERSEN, F;OLSEN, NV
通讯作者：
OLSEN, NV