LIPOSOMES AS DRUG DELIVERY SYSTEM IN THE TREATMENT OF INFECTIOUS-DISEASES - POTENTIAL APPLICATIONS AND CLINICAL-EXPERIENCE
LIPOSOMES AS DRUG DELIVERY SYSTEM IN THE TREATMENT OF INFECTIOUS-DISEASES - POTENTIAL APPLICATIONS AND CLINICAL-EXPERIENCE
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DOI：
10.1007/bf01644088
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发表时间：
1988-05-01
期刊：
影响因子：
7.5
通讯作者：
COUNE, A
中科院分区：
文献类型：
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作者：
COUNE, A
脂质体是微观的、封闭的脂质囊泡，能够捕获亲水性和亲脂性化合物。它们构成了一种通用的药物递送系统。当通过静脉途径注射时，脂质体被肝脏和脾脏中的巨噬细胞摄取。对几种感染动物模型的研究表明，脂质体包埋的抗感染药物对由兼性细胞内细菌、寄生虫如利什曼原虫、病毒如引起裂谷热的病毒引起的感染具有活性。不同脂质组成、结构和大小的脂质体用于抗感染药物的静脉内给药，而不会在受试动物中诱导毒性。临床经验获得了两种不同的脂质体制剂的阿替霉素B在治疗癌症患者的全身性真菌疾病，这些制剂被证明是有效的，非常好的耐受性。
Liposomes are microscopic, closed lipid vesicles able to entrap hydrophilic as well as lipophilic compounds. They constitute a versatile drug delivery system. When injected by the intravenous route, liposomes are taken up by macrophages in the liver and in the spleen. Investigation of several animal models of infections has shown that liposome-entrapped anti-infectious drugs are active against infections due to facultative intracellular bacteria, parasites such as Leishmania, viruses such as the one causing Rift valley fever. Liposomes of different lipid compositions, structures and sizes were used for intravenous administration of anti-infectious drugs without inducing toxicity in the tested animals. Clinical experience was obtained with two different liposomal preparations of amphotericin B in the treatment of systemic fungal diseases in cancer patients; these preparations were shown to be effective and very well-tolerated.