Graphene-based nanovehicles for photodynamic medical therapy.
Graphene-based nanovehicles for photodynamic medical therapy.
复制标题
用于光动力医学治疗的石墨烯纳米载体
DOI：
10.2147/ijn.s68600
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发表时间：
2015
影响因子：
8
通讯作者：
Shi D
中科院分区：
文献类型：
--
作者：
Li Y;Dong H;Li Y;Shi D
石墨烯及其衍生物如氧化石墨烯（GO）已被广泛探索为用于改善癌症治疗的有前景的药物递送载体。本文就其在光动力学治疗中的应用作一综述。GO的大比表面积有利于通过各种表面官能团有效负载光敏剂和生物分子。通过掺入靶向配体或响应于特定生物刺激的可活化剂，建立了智能纳米载体，使得能够实现光敏剂的肿瘤触发释放或肿瘤选择性积累，用于具有最小副作用的有效治疗。石墨烯基纳米系统已被证明可以提高有机光敏剂分子的稳定性、生物利用度和光动力学效率。它们也被证明是增强可见光光动力活性的电子汇。由于其固有的近红外吸收特性，GO可以被设计为联合收割机组合光动力和光热热疗以获得最佳治疗效率。本文就光动力学疗法研究的关键问题和未来发展方向进行了综述。
Graphene and its derivatives such as graphene oxide (GO) have been widely explored as promising drug delivery vehicles for improved cancer treatment. In this review, we focus on their applications in photodynamic therapy. The large specific surface area of GO facilitates efficient loading of the photosensitizers and biological molecules via various surface functional groups. By incorporation of targeting ligands or activatable agents responsive to specific biological stimulations, smart nanovehicles are established, enabling tumor-triggering release or tumor-selective accumulation of photosensitizer for effective therapy with minimum side effects. Graphene-based nanosystems have been shown to improve the stability, bioavailability, and photodynamic efficiency of organic photosensitizer molecules. They have also been shown to behave as electron sinks for enhanced visible-light photodynamic activities. Owing to its intrinsic near infrared absorption properties, GO can be designed to combine both photodynamic and photothermal hyperthermia for optimum therapeutic efficiency. Critical issues and future aspects of photodynamic therapy research are addressed in this review.