Contrast-enhanced spectral mammography with a photon-counting detector
Contrast-enhanced spectral mammography with a photon-counting detector
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DOI：
10.1118/1.3371689
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发表时间：
2010-05-01
期刊：
影响因子：
3.8
通讯作者：
Danielsson, Mats
中科院分区：
文献类型：
--
作者：
Fredenberg, Erik;Hemmendorff, Magnus;Danielsson, Mats
方法：建立了一个包含量子噪声和解剖噪声的系统表征框架，并以体模测量为基准建立了系统的理论模型。结果：能量分辨图像的最优组合近似对应于解剖噪声的最小化，这通常被称为能量减法。在这种情况下，与体模研究中的吸收成像相比，理想观察者的可探测性指数可以提高近50%。关于信号与量子噪声比的优化，通常被称为能量加权，只产生了微小的改善。在一个临床上更真实的病例的模拟中，对于具有平均水平的解剖噪声的平均腺体乳房，光谱成像被预测比吸收成像执行大约30%的性能。然而，对于致密的乳房组织和高水平的解剖噪音，可探测性上升了6倍。另一项类似于70%-90%的改进被发现在优化的系统中触手可及。结论：对比度增强的光谱乳房摄影是可行的，对现有系统是有益的，还有进一步改进的空间。包含解剖噪声对于优化光谱成像系统是必不可少的。
Methods: A framework for system characterization was set up that included quantum and anatomical noise and a theoretical model of the system was benchmarked to phantom measurements.Results: Optimal combination of the energy-resolved images corresponded approximately to minimization of the anatomical noise, which is commonly referred to as energy subtraction. In that case, an ideal-observer detectability index could be improved close to 50% compared to absorption imaging in the phantom study. Optimization with respect to the signal-to-quantum-noise ratio, commonly referred to as energy weighting, yielded only a minute improvement. In a simulation of a clinically more realistic case, spectral imaging was predicted to perform approximately 30% better than absorption imaging for an average glandularity breast with an average level of anatomical noise. For dense breast tissue and a high level of anatomical noise, however, a rise in detectability by a factor of 6 was predicted. Another similar to 70%-90% improvement was found to be within reach for an optimized system.Conclusions: Contrast-enhanced spectral mammography is feasible and beneficial with the current system, and there is room for additional improvements. Inclusion of anatomical noise is essential for optimizing spectral imaging systems.