Case Studies in Neuroscience: Sensations elicited and discrimination ability from nerve cuff stimulation in an amputee over time
Case Studies in Neuroscience: Sensations elicited and discrimination ability from nerve cuff stimulation in an amputee over time
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DOI：
10.1152/jn.00909.2017
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发表时间：
2018-07-01
影响因子：
2.5
通讯作者：
Wessberg, Johan
中科院分区：
文献类型：
--
作者：
Ackerley, Rochelle;Wasling, Helena Backlund;Wessberg, Johan
本案例研究详细介绍了经肱骨截肢的参与者使用植入的神经袖带电极对周围神经轴突进行电刺激所引起的感觉。参与者使用骨集成机电接口，使假肢能够附着在骨骼上，并在植入电极和假肢之间实现长期、稳定、双向的通信。我们专注于唤起体感感知，跟踪并量化缺失手的感知感觉的演变。这是由神经电刺激引起的，持续了两年多。这些感觉包括振动或推动的小点状区域，到更广泛区域的较大感觉，分别表明招募了一些和许多传入神经。此外，我们使用两种替代的强制选择范式来测量一系列短暂电刺激之间的辨别水平，以衡量参与者可以可靠地区分的内容。最好的情况下，参与者能够区分 05 Hz 的差异，并且在更严格的心理物理水平上平均获得 3.8 Hz 的刚刚可察觉的差异。目前的工作表明，通过电轴突刺激，在假肢中进行长期感觉反馈的可行性，其中感觉到小的且相对稳定的感知，可用于提供分级的感觉反馈。这为运动过程中的信号反馈（例如精确抓握）提供了机会，也为传达更复杂的皮肤感觉提供了机会。例如纹理。新的和值得注意的我们展示了截肢者周围神经电刺激的长期稳定性和感觉的产生。通过骨整合植入物。我们发现感知到的触觉可以产生超过 2 年的时间。在失踪的手上。这对于假肢开发和人造身体部位反馈的实施非常有用。
The present case study details sensations elicited by electrical stimulation of peripheral nerve axons using an implanted nerve cuff electrode, in a participant with a transhumeral amputation. The participant uses an osseointegrated electromechanical interface, which enables skeletal attachment of the prosthesis and long-term, stable, bidirectional communication between the implanted electrodes and prosthetic arm. We focused on evoking somatosensory percepts, where we tracked and quantified the evolution of perceived sensations in the missing hand. which were evoked from electrical stimulation of the nerve, for over 2 yr. These sensations included small, pointlike areas of either vibration or pushing, to larger sensations over wider areas, indicating the recruitment of a few and many afferents, respectively. Furthermore, we used a two-alternative forced choice paradigm to measure the level of discrimination between trains of brief electrical stimuli, to gauge what the participant could reliably distinguish between. At best, the participant was able to distinguish a 05-Hz difference and on average acquired a 3.8-Hz just-noticeable difference at a more stringent psychophysical level. The current work shows the feasibility for long-term sensory feedback in prostheses, via electrical axonal stimulation, where small and relatively stable percepts were felt that may be used to deliver graded sensory feedback. This opens up opportunities for signaling feedback during movements (e.g., for precision grip), but also for conveying more complex cutaneous sensations. such as texture.NEW & NOTEWORTHY We demonstrate the long-term stability and generation of sensations from electrical peripheral nerve stimulation in an amputee. through an osseointegrated implant. We find that perceived tactilelike sensations could be generated for over 2 yr. in the missing hand. This is useful for prosthetic development and the implementation of feedback in artificial body parts.