Salivary cortisol in a middle-aged community sample: results from 990 men and women of the KORA-F3 Augsburg study
Salivary cortisol in a middle-aged community sample: results from 990 men and women of the KORA-F3 Augsburg study
复制标题
中年社区样本唾液皮质醇：KORA-F3 奥格斯堡研究中 990 名男性和女性的结果
DOI：
10.1530/eje-10-0491
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发表时间：
2010-09-01
影响因子：
5.8
通讯作者：
Ladwig, Karl-Heinz
中科院分区：
文献类型：
--
作者：
Lederbogen, Florian;Kuehner, Christine;Ladwig, Karl-Heinz
目的：唾液皮质醇浓度及其衍生指标的分析在临床和科学医学中的应用日益广泛。然而，关于一般人群中这些参数的全面数据很少。本研究的目的是评估唾液皮质醇的浓度在一个大的中年社区样本，并确定与改变激素levels.Design的主要因素：我们进行了一项横断面研究，在奥格斯堡地区的合作健康研究（KORA）-F3研究。共有1484名年龄在50-69岁（52%的妇女）的参与者同意提供四个唾液样本在一个普通的weekday.Methods：我们测量了唾液皮质醇浓度在醒来后（F0），1/2小时（F1/2），8小时（F8），14小时（F14）。我们计算了皮质醇觉醒反应（CAR）、斜率和昼夜皮质醇分泌的曲线下面积（AUC（G））。通过访谈和问卷调查评估社会人口学和临床特征，采样条件由协议决定。总共有1208名参与者返回唾液样本，排除标准留下990名受试者进行最终分析。F0 = 13.7 +/- 7.6，F1/2 = 20.5 +/- 9.8，F8 = 5.4 +/- 3.3，F14 = 2.0 +/- 1.8 nmol/l。较早的采样时间与较高的CAR和较小的斜率相关。皮质醇的分泌也受到性别和吸烟习惯的影响。较高的感知社会支持与较低的AUC（G）和较小的slope.Conclusions：我们提供的数据唾液皮质醇浓度在一个大的中年社区样本。性别、采样时间、吸烟习惯和感知社会支持是皮质醇分泌的决定因素。
Objective: Analysis of salivary cortisol concentrations and derived indices is increasingly used in clinical and scientific medicine. However, comprehensive data on these parameters in the general population are scarce. The aim of this study was to evaluate the concentrations of salivary cortisol in a large middle-aged community sample and to identify major factors associated with altered hormone levels.Design: We conducted a cross-sectional study within the Cooperative Health Research in the Region of Augsburg (KORA)-F3 study. A total of 1484 participants aged 50-69 years (52% women) had agreed to provide four saliva samples during a regular weekday.Methods: We measured salivary cortisol concentrations at wake-up (F0), 1/2 h (F1/2), 8 h (F8), and 14 h (F14) after waking. We calculated cortisol awakening response (CAR), slope, and area under the curve (AUC(G)) of the circadian cortisol secretion. Sociodemographic and clinical characteristics were evaluated by interview and questionnaires, sampling conditions by protocol. In total, 1208 participants returned saliva samples, exclusion criteria left 990 subjects for final analyses.Results: Salivary cortisol levels were (means +/- S.D.) F0 = 13.7 +/- 7.6, F1/2 = 20.5 +/- 9.8, F8 = 5.4 +/- 3.3, and F14 = 2.0 +/- 1.8 nmol/l. Earlier sampling times were associated with higher CAR and smaller slope. Cortisol secretion was also influenced by gender and smoking habits. Higher perceived social support was associated with lower AUC(G) and smaller slope.Conclusions: We provide data on salivary cortisol concentrations in a large middle-aged community sample. Gender, sampling time, smoking habits, and perceived social support appeared as determinants of cortisol secretion.