Increase in incidence and prevalence of inflammatory bowel disease in northern Denmark: a population-based study, 1978-2002
Increase in incidence and prevalence of inflammatory bowel disease in northern Denmark: a population-based study, 1978-2002
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DOI：
10.1097/00042737-200606000-00005
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发表时间：
2006-06-01
影响因子：
2.1
通讯作者：
Sorensen, Henrik T.
中科院分区：
文献类型：
--
作者：
Jacobsen, Bent A.;Fallingborg, Jan;Sorensen, Henrik T.
目标。尽管全世界都报道了炎症性肠病的发病率，但很少有基于人群的长期研究带有当前的时间趋势分析。因此，我们在25年的研究期间考察了炎症性肠病发病率的时间趋势，并估计了2002年的发病率。所有在1978-2002年确诊的病例被纳入发病病例(n=2326)，2002年12月31日居住在北Jutland县的所有病例被用来估计流行病例(n=2205)。回顾了北日德兰县医院出院登记处所有被诊断为溃疡性结肠炎和克罗恩病的患者的病历，以检查是否符合诊断标准。计算不同年龄和不同性别的标化发病率。女性溃疡性结肠炎的发病率从1978年至1982年的8.3%(95%可信区间：6.7-9.9)上升到1998年-2002年的每100000人年17.0(95%可信区间：14.7-19.3)。男性的相应数字为每10万人年77人(95%氯：6.1-9.3)和16.7(95%氯：14.4-18.8)。对于克罗恩病，妇女发病率从1978-1982年的4.1(95%CI：3.0-5.2)上升到1998-2002年的10.7(95%CI：8.8-12.5)/10万人年。男性的相应数字为每10万人年3.2(95%氯：2.1-4.2)和8.5(95%氯：6.9-10.2)。溃疡性结肠炎和克罗恩病的患病率分别为294/10万和151/10万。在过去的25年里，溃疡性结肠炎和克罗恩病在男女中都有显著的平行增加，这两种疾病的患病率都相应地很高。
Objectives. Although incidence rates of inflammatory bowel disease have been reported worldwide, few long-term population-based studies with current time-trend analyses exist. We therefore examined time trends in the incidence rate of inflammatory bowel disease in a 25-year study period, and estimated the prevalence in 2002. All patients diagnosed between 1978 and 2002 were included as incident cases (n=2326) and all patients living in North Jutland County on 31 December 2002 were used to estimate prevalent cases (n=2205).Methods. Medical records of all patients diagnosed with ulcerative colitis and Crohn's disease in the North Jutland County Hospital Discharge Registry were reviewed to examine if the diagnostic criteria were fulfilled. Age-specific and gender-specific standardized incidence rates were calculated.Results. For ulcerative colitis, incidence rates in women increased from 8.3 (95% confidence interval (Cl): 6.7-9.9) in 1978-1982 to 17.0 (95% Cl: 14.7-19.3) per 100000 person-years in 1998-2002. The corresponding figures for men were 77 (95% Cl: 6.1-9.3) and 16.7 (95% Cl: 14.4-18.8) per 100 000 person-years. For Crohn's disease, the incidence rates in women increased from 4.1 (95% Cl: 3.0-5.2) in 1978-1982 to 10.7 (95% Cl: 8.8-12.5) per 100 000 person-years in 1998-2002. The corresponding figures for men were 3.2 (95% Cl: 2.1-4.2) and 8.5 (95% Cl: 6.9-10.2) per 100 000 person-years. The prevalence of ulcerative colitis and Crohn's disease was 294 and 151 per 100 000 inhabitants, respectively.Conclusions. A marked and parallel increase was seen in both ulcerative colitis and Crohn's disease in both genders during the last 25 years, with a corresponding high prevalence of both diseases.