Diselenides as proxies of disulfides in cystine-rich peptides
Diselenides as proxies of disulfides in cystine-rich peptides
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二硒化物作为富含胱氨酸的肽中二硫化物的替代物
DOI：
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
L. Moroder
中科院分区：
文献类型：
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作者：
H. Musiol;L. Moroder
我们的小组今年提出了为连续流动化学设计的非谐振微波发生器的概念。该仪器的输出功率为0 - 150 W，可调频率范围为2.4 - 2.5 GHz，五个红外传感器沿着管式硼硅酸盐反应器监测温度，可确保快速、高效和均匀的加热。使用200 mm x空组3 mm反应器对连续流动化学的各种有机反应进行了优化，这证明该仪器是快速方法优化的前所未有的工具。现在报道了一种扩大研究，其中已经在空的3 mm反应器中优化的反应在空的6 mm反应器中进行，目的是在不需要或几乎不需要重新优化的情况下使化学品通量增加四倍。
The concept of a non-resonant microwave applicator designed for continuous flow chemistry was introduced by our group this year. With a power output of 0 - 150 W, adjustable frequency range of 2.4 - 2.5 GHz and five IR sensors monitoring the temperature along a tubular borosilicate reactor, the instrument ensures fast, efficient and uniform heating. A variety of organic reactions were optimized for continuous flow chemistry using a 200 mm x empty set 3 mm reactor, which proved the instrument to be an unprecedented tool for fast method optimization. A scale-out study is now reported where reactions already optimized in a empty set 3 mm reactor are run in a empty set 6 mm reactor, aiming for a fourfold increase in chemical throughput with no or little need for re-optimization.