Circulating glycotoxins and dietary advanced glycation endproducts: Two links to inflammatory response, oxidative stress, and aging
Circulating glycotoxins and dietary advanced glycation endproducts: Two links to inflammatory response, oxidative stress, and aging
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DOI：
10.1093/gerona/62.4.427
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发表时间：
2007-04-01
影响因子：
5.1
通讯作者：
Vlassara, Helen
中科院分区：
文献类型：
--
作者：
Uribarri, Jaime;Cai, Weiiing;Vlassara, Helen
背景氧化应激（OS）和炎症介质随着年龄的增长而增加。晚期糖基化终产物（AGEs）的水平，与慢性疾病如糖尿病，心血管疾病和肾脏疾病相关的促氧化因子，也随着衰老而增加。AGEs很容易从热处理的食物中提取。我们认为，通过饮食过量摄入某些AGEs会增强健康成年人的OS和炎症反应，尤其是老年人。我们检查了172名年轻（60岁）健康个体，以确定老年人的特异性血清AGEs（N ε-羧甲基赖氨酸[CML]或甲基乙二醛[MG]衍生物）浓度是否高于年轻人，以及是否与年龄无关，与饮食AGEs摄入量以及OS和炎症的循环标志物相关。体重、体重指数（BMI）和血清AGE、CML和MG衍生物在老年参与者中较高，与性别无关。血清CML与8-异前列腺素水平（r = 0.448，p = 0.0001）以及胰岛素抵抗指数（HOMA）（r = 0.247，p = 0.044）相关。饮食中AGEs的消耗量与循环AGEs（CML：r = 0.415，p = 0.0001和MG：r = 0.282，p = 0.002）以及高敏C反应蛋白（hsCRP）（r = 0.200，p = 0.042）独立相关，但与卡路里无关。AGEs的循环指标（CML和MG衍生物），虽然在老年参与者中升高，但与所有年龄段的炎症和OS指标相关。AGEs和OS的指标直接受饮食AGEs摄入量的影响，与年龄或能量摄入无关。因此，减少这些氧化剂的消费可能被证明是预防与年龄有关的疾病的安全经济政策，特别是在老龄化人口中。
Background. Oxidative stress (OS) and inflammatory mediators increase with aging. The levels of advanced glycation endproducts (AGEs), prooxidant factors linked to chronic diseases such as diabetes, cardiovascular disease, and renal disease, also increase with aging. AGEs are readily derived from heat-treated foods. We propose that the excess consumption of certain AGEs via the diet enhances OS and inflammatory responses in healthy adults, especially in elderly persons.Methods. We examined 172 young (60 years old) healthy individuals to determine whether the concentration of specific serum AGEs (N epsilon-carboxymethyl-lysine [CML] or methylglyoxal [MG] derivatives) were higher in older compared to younger persons and whether, independent of age, they correlated with the intake of dietary AGEs, as well as with circulating markers of OS and inflammation.Results. Body weight, body mass index (BMI), and serum AGE, CML, and MG derivatives were higher in older participants, independent of gender. Serum CML correlated with levels of 8-isoprostanes (r = 0.448, p = .0001) as well as with Homeostasis Model Assessment index (HOMA), an index of insulin resistance (r = 0.247, p = .044). The consumption of dietary AGEs, but not of calories, correlated independently with circulating AGEs (CML: r = 0.415, p = .0001 and MG: r = 0.282, p = .002) as well as with high sensitivity C-reactive protein (hsCRP) (r = 0.200, p = .042).Conclusions. Circulating indicators of AGEs (CML and MG derivatives), although elevated in older participants, correlate with indicators of inflammation and OS across all ages. Indicators of both AGEs and OS are directly influenced by the intake of dietary AGEs, independent of age or energy intake. Thus, reduced consumption of these oxidants may prove a safe economic policy to prevent age-related diseases, especially in an aging population.