RELATIONSHIP BETWEEN MITOCHONDRIAL SUPEROXIDE AND HYDROGEN-PEROXIDE PRODUCTION AND LONGEVITY OF MAMMALIAN-SPECIES
RELATIONSHIP BETWEEN MITOCHONDRIAL SUPEROXIDE AND HYDROGEN-PEROXIDE PRODUCTION AND LONGEVITY OF MAMMALIAN-SPECIES
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DOI：
10.1016/0891-5849(93)90165-q
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发表时间：
1993-12-01
影响因子：
7.4
通讯作者：
SOHAL, RS
中科院分区：
文献类型：
--
作者：
KU, HH;BRUNK, UT;SOHAL, RS
本研究的目的是检查氧自由基在衰老过程中可能的参与。比较了七种不同哺乳动物物种（小鼠、仓鼠、大鼠、豚鼠、兔子、猪和牛）的线粒体 O2.- 和 H2O2 生成率以及肾脏和心脏的耗氧量，这些哺乳动物的最大寿命潜力（MLSP）从 3.5 到 30 年不等。线粒体O2.-和H2O2生成率与MLSP呈负相关，与特定代谢率和状态4线粒体呼吸直接相关。这项研究的结果表明，在相同条件下，寿命较短物种的线粒体比寿命较长物种的线粒体产生相对更高数量的活性氧，因此支持衰老的自由基假说。
The objective of this study was to examine the possible involvement of oxygen free radicals in the aging process. Rates of mitochondrial O2.- and H2O2 production and oxygen consumption in the kidney and the heart were compared among seven different mammalian species namely, mouse, hamster, rat, guinea pig, rabbit, pig, and cow, whose maximum life span potential (MLSP) varies from 3.5 to 30 years. The rates of mitochondrial O2.- and H2O2 generation were inversely correlated to MLSP, and directly related to specific metabolic rate and state 4 mitochondrial respiration. Results of this study indicate that under identical conditions, mitochondria from shorter-lived species produce relatively higher amounts of reactive oxygen species than those from the longer-lived species, and, thus, support the free radical hypothesis of aging.