D1-like and D2 dopamine receptor antagonists administered into the shell subregion of the rat nucleus accumbens decrease cocaine, but not food, reinforcement
D1-like and D2 dopamine receptor antagonists administered into the shell subregion of the rat nucleus accumbens decrease cocaine, but not food, reinforcement
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DOI：
10.1016/j.neuroscience.2005.06.048
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发表时间：
2005-01-01
期刊：
影响因子：
3.3
通讯作者：
Pierce, RC
中科院分区：
文献类型：
--
作者：
Bari, AA;Pierce, RC
设计了可卡因自我给药实验，以评估腹侧前脑中D1样和D2样多巴胺受体在可卡因强化中的作用。将D1样或D2样多巴胺受体拮抗剂显微注射到伏核核心、伏隔核壳、新纹状体或外侧隔区，然后以递增比例程序自行给予可卡因。结果表明，伏核核壳和核内注射多巴胺受体拮抗剂D_1/5(SCH-23390)或D_2/D_3/D_4(依替氯必利)，而不给予D_3(U99194A)或D_4(L-750,667)，则可卡因的增强效应减弱。然而，在对照实验中，伏隔内核心给药SCH-23390或乙氯必利减少了食物自我给药，而将这些药物注入伏隔壳内对食物强化没有影响。SCH-23390和乙氯必利均不影响新纹状体或外侧隔区的可卡因强化。综上所述，这些结果表明伏核外壳中的D1样和D2多巴胺受体选择性地调节可卡因的增强效应，而伏隔核中的D1样和D2多巴胺受体对增强行为有更普遍的影响。(C)2005年由爱思唯尔有限公司代表IBRO出版。
Cocaine self-administration experiments were designed to assess the respective roles of D1-like and D2-like dopamine receptors in the ventral forebrain in cocaine reinforcement. D1-like or D2-like dopamine receptor antagonists were microinjected into the nucleus accumbens core, nucleus accumbens shell, neostriatum or lateral septum prior to sessions in which cocaine was self-administered under a progressive ratio schedule by rats. The results indicated that administration of a D1/5 (SCH-23390) or a D2/D3/D4 (eticlopride), but not a D3 (U99194A) or D4 (L-750,667), dopamine receptor antagonist into the core and shell of the nucleus accumbens decreased the reinforcing efficacy of cocaine. However, in control experiments intra-accumbal core administration of SCH-23390 or eticlopride decreased food self-administration, whereas administration of these drugs into the accumbens shell had no effect on food reinforcement. Neither SCH-23390 nor eticlopride influenced cocaine reinforcement when administered into the neostriatum or lateral septum. Collectively, these results indicate that D1-like and D2 dopamine receptors in the nucleus accumbens shell selectively modulate the reinforcing efficacy of cocaine, whereas D1-like and D2 dopamine receptors in the accumbens core have a more general influence on reinforced behaviors. (c) 2005 Published by Elsevier Ltd on behalf of IBRO.