The Total Synthesis of Diquinane‐Containing Natural Products
The Total Synthesis of Diquinane‐Containing Natural Products
复制标题
二喹烷天然产物的全合成
DOI：
10.1002/chem.202003741
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Xuegong She
中科院分区：
文献类型：
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作者：
Huilin Li;Jing Zhang;Xuegong She
二醌或双环[3.3.0]辛烷是广泛存在于天然产物如生物碱和萜类化合物的碳骨架中的显著结构单元。这些含二醌的分子不仅表现出有趣的结构，而且还展示了广泛的重要生物活性，引起了全球合成界的广泛关注。在过去的十年中，为了实现天然产物的这种特定的丰饶的全合成，已经公开了用于构建二醌环系统的各种优雅的策略。在这个小审查中，展示了从2010年到2020年6月的时间轴中在这个主题上取得的成就，并讨论了如何在特定目标结构的背景下战略性地锻造二醌单元。此外，还重点介绍了所选工作对天然产物全合成领域的影响，并对含二醌天然产物的合成进行了展望。
Diquinane or bicyclo[3.3.0]octane is a conspicuous structural unit existing in the carbo‐frameworks of a wide range of natural products such as alkaloids and terpenoids. These diquinane‐containing molecules not merely exhibit intriguing architectures, but also showcase a broad spectrum of significant bioactivities, which draw widespread attention from the global synthetic community. During the past decade, with an aim to accomplish the total syntheses of such specified cornucopias of natural products, a variety of elegant strategies for construction of the diquinane ring system have been disclosed. In this Minireview, the achievements on this subject in the timeline from 2010 to June 2020 are demonstrated and it is discussed how the diquinane unit is strategically forged in the context of the specific target structure. In addition, impacts of the selected works to the field of natural product total synthesis is highlighted and the particular outlook of diquinane‐containing natural product synthesis is provided.